{"id":"W2790489252","doi":"10.1016/j.yexcr.2018.02.032","title":"Anti-tumor effect of AZD8055 against neuroblastoma cells in vitro and in vivo","year":2018,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Ministry of Health, British Columbia","keywords":"PI3K/AKT/mTOR pathway; mTORC1; mTORC2; Biology; Neuroblastoma; Protein kinase B; Cell growth; Apoptosis; Cancer research; Autophagy; Cell culture; Biochemistry; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002175368,0.0006598982,0.0008148075,0.0005878017,0.000294148,0.000271407,0.0005442854,0.0003752513,0.002060312],"category_scores_gemma":[0.0001489599,0.0002073613,0.0004323992,0.0002849966,0.0003390265,0.0003317081,0.0001762704,0.001113258,0.0005015026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000440906,"about_ca_system_score_gemma":0.0006890532,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003496225,"about_ca_topic_score_gemma":0.004007498,"domain_scores_codex":[0.9997926,0.00003036615,0.0000190294,0.00003096067,0.00004072359,0.00008627573],"domain_scores_gemma":[0.9999375,0.00001232176,0.000009259358,0.00001302744,0.000007859229,0.00001993615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003519826,0.001658428,0.000850893,0.0003104384,0.0001272876,0.0001834882,0.00008104181,0.001341278,0.9659411,0.0004353012,0.001281702,0.02426925],"study_design_scores_gemma":[0.0005527763,0.009021451,0.009029572,0.00001926806,0.0002080477,0.0004752078,0.00006091808,0.002084591,0.9720416,0.00009084007,0.006393693,0.00002216049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891798,0.004981368,0.0007936999,0.0002899209,0.0001886501,0.00006998104,0.0007421466,0.0001682606,0.003586073],"genre_scores_gemma":[0.9907249,0.003808214,0.0007613726,0.00008198964,0.00003671451,0.0000570012,0.001253763,0.000014935,0.003261189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003496225,"threshold_uncertainty_score":0.006951749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02266971435030028,"score_gpt":0.3631839407184702,"score_spread":0.3405142263681699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}