{"id":"W2790504833","doi":"10.1016/j.biopha.2018.01.127","title":"Bucindolol attenuates the vascular remodeling of pulmonary arteries by modulating the expression of the endothelin-1 A receptor in rats with pulmonary arterial hypertension","year":2018,"lang":"en","type":"article","venue":"Biomedicine & Pharmacotherapy","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lakehead University; NOSM University","funders":"Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","keywords":"Endothelin 1; Endothelin receptor; Medicine; Pulmonary hypertension; Internal medicine; Cardiology; Pulmonary vasculature; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002232954,0.0006317848,0.0006960048,0.0004401172,0.0003086948,0.0002682556,0.0004812231,0.0004920433,0.002034705],"category_scores_gemma":[0.0002400555,0.0002953032,0.0003542247,0.0001960256,0.0006809014,0.0006478547,0.0002316266,0.002187748,0.0002603326],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002534585,"about_ca_system_score_gemma":0.0004858776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00087898,"about_ca_topic_score_gemma":0.001052207,"domain_scores_codex":[0.9998218,0.00002753937,0.00001489709,0.00002644342,0.00004479845,0.00006454262],"domain_scores_gemma":[0.9997743,0.00001732783,0.00007202703,0.00002180123,0.00002618354,0.00008844972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007462546,0.001649422,0.0006066818,0.0001657329,0.00003205821,0.000213155,0.00005857869,0.0001010434,0.9796679,0.0002676191,0.0001868546,0.009588392],"study_design_scores_gemma":[0.001596063,0.01631597,0.02435841,0.00003070311,0.0002682013,0.0005213125,0.0002780293,0.00286828,0.949694,0.0003254588,0.003702943,0.00004055947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995262,0.001676079,0.001613411,0.0003391675,0.0001102169,0.00003826307,0.0001143942,0.000117681,0.0007286899],"genre_scores_gemma":[0.9914887,0.002600159,0.001816539,0.0001601454,0.0001067858,0.0001221589,0.0002113957,0.00002463215,0.003469463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002034705,"threshold_uncertainty_score":0.006806731,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02456764880225694,"score_gpt":0.2883021974612489,"score_spread":0.2637345486589919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}