{"id":"W2790526079","doi":"10.1101/277434","title":"Inhibition of IRAK4 by microbial trimethylamine blunts metabolic inflammation and ameliorates glycemic control","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Medical Research Council; Wellcome Trust","keywords":"Kinome; Insulin resistance; Microbiome; Biology; Immune system; Metabolome; Inflammation; TLR4; Insulin receptor; Trimethylamine N-oxide; Receptor; Cell biology; Insulin; Biochemistry; Endocrinology; Immunology; Signal transduction; Metabolite; Trimethylamine; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001439753,0.000330916,0.0002660922,0.0001814797,0.0001164934,0.0002139849,0.000250328,0.0002631349,0.003392363],"category_scores_gemma":[0.00008116631,0.0001071773,0.0002366053,0.00009237954,0.0001888927,0.0001678906,0.0001868624,0.0007654075,0.0005509856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002176594,"about_ca_system_score_gemma":0.0002257631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003134353,"about_ca_topic_score_gemma":0.000445402,"domain_scores_codex":[0.9999204,0.0000158076,0.000008555296,0.00001601348,0.00001844505,0.00002075762],"domain_scores_gemma":[0.9999522,0.000004798735,0.00001926005,0.000006642577,0.00000549367,0.00001155946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001028415,0.0001049644,0.0001915233,0.000103125,0.00002165016,0.00002892676,0.000006109738,0.0001449823,0.9932501,0.0001508185,0.0002906054,0.004678729],"study_design_scores_gemma":[0.0001356898,0.001117403,0.002458445,0.00001346676,0.00003067849,0.0001262824,0.00001726992,0.00103563,0.990329,0.0001227482,0.004606298,0.000007074473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9738643,0.01003534,0.008402811,0.001036215,0.0003144775,0.00007633092,0.001051901,0.0005309091,0.004687693],"genre_scores_gemma":[0.9853771,0.002965769,0.004808857,0.0003067337,0.00004304941,0.00007864115,0.0005783889,0.00003834865,0.005803191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003392363,"threshold_uncertainty_score":0.01134861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006245820978492266,"score_gpt":0.2155646018808814,"score_spread":0.2093187809023892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}