{"id":"W2790580707","doi":"10.1111/cmi.12824","title":"Lysosome remodelling and adaptation during phagocyte activation","year":2018,"lang":"en","type":"review","venue":"Cellular Microbiology","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Canada Research Chairs; Ryerson University","keywords":"TFEB; Lysosome; Autophagy; Cell biology; Biology; Phagocytosis; Antigen presentation; Phagocyte; Endocytosis; Cellular adaptation; Macrophage; Immune system; Immunology; Cell; T cell; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000376057,0.0005905441,0.0008818158,0.001844949,0.0003042137,0.001004741,0.0005773957,0.001177509,0.001800753],"category_scores_gemma":[0.0004306443,0.0002137084,0.0004056391,0.001188142,0.0005042987,0.001237586,0.0007155594,0.001312672,0.001468528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008073789,"about_ca_system_score_gemma":0.0008366893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007460272,"about_ca_topic_score_gemma":0.00105249,"domain_scores_codex":[0.999845,0.00001867075,0.00002626583,0.00003304618,0.00005549917,0.00002148949],"domain_scores_gemma":[0.9998624,0.00004113237,0.00002623817,0.000005937751,0.00004559282,0.00001865093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009938289,0.0000518182,0.0003519047,0.01502526,0.00006841386,0.000506565,0.0001341767,0.0005908271,0.006760918,0.01063625,0.02603318,0.9397413],"study_design_scores_gemma":[0.00000660709,0.00006487926,0.00097728,0.001762435,0.00003997526,0.002212967,0.00006577218,0.0001134209,0.001855298,0.002899007,0.9899827,0.00001975676],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002843464,0.997361,0.0002977904,0.0003332952,0.0002511349,0.000005970592,0.00002642116,0.00001584581,0.001424139],"genre_scores_gemma":[0.001620605,0.9969622,0.0002648418,0.0002019569,0.0001277098,0.00000870361,0.00003927181,0.000002573032,0.0007721126],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001844949,"threshold_uncertainty_score":0.006024122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05393045998787303,"score_gpt":0.3008934672786037,"score_spread":0.2469630072907307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}