{"id":"W2790606657","doi":"10.1016/j.cub.2018.02.002","title":"Mps1 Phosphorylates Its N-Terminal Extension to Relieve Autoinhibition and Activate the Spindle Assembly Checkpoint","year":2018,"lang":"en","type":"article","venue":"Current Biology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"National Institute of General Medical Sciences; Fonds de Recherche du Québec - Santé; National Cancer Institute; National Institutes of Health; Darwin Trust of Edinburgh; Wellcome Trust; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Kinetochore; Autophosphorylation; Cell biology; Mitosis; Biology; Spindle checkpoint; Protein subunit; Phosphorylation; Protein kinase A; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008309167,0.000241773,0.00008447929,0.00008689441,0.0001008739,0.0001735691,0.0001216433,0.0001145479,0.001886753],"category_scores_gemma":[0.0001023411,0.00007327434,0.0001308022,0.00004049471,0.0001248264,0.000180962,0.0002115597,0.0002595628,0.0005570382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002037317,"about_ca_system_score_gemma":0.000126787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001680046,"about_ca_topic_score_gemma":0.0003182194,"domain_scores_codex":[0.9999597,0.000006085777,0.000003469755,0.00001291979,0.000009360193,0.000008433711],"domain_scores_gemma":[0.9999512,0.000008467245,0.00001574156,0.000005763388,0.000003945811,0.00001486062],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007833729,0.00001061954,0.0002353291,0.00002543297,0.000003037263,0.00005536582,0.000006699492,0.00008872427,0.9980212,0.0001229928,0.00004112175,0.001311098],"study_design_scores_gemma":[0.00001017894,0.00006683484,0.008818906,0.000004424826,0.000006280351,0.0003365364,0.00001556039,0.001290609,0.9864984,0.00009301656,0.002855581,0.000003772157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955787,0.0009192676,0.001556442,0.00006458588,0.00001786561,0.000008759099,0.000118577,0.00004467883,0.001691101],"genre_scores_gemma":[0.996106,0.0003548612,0.0008655105,0.00002089142,0.00001012832,0.00000744347,0.0002144374,0.00001110264,0.002409522],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001886753,"threshold_uncertainty_score":0.006311834,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01849633964362981,"score_gpt":0.2976995020124081,"score_spread":0.2792031623687783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}