{"id":"W2790621413","doi":"","title":"Risk stratification and targeted neuroprotection in Parkinson disease utilising the glucocerebrosidase pathway","year":2018,"lang":"en","type":"dissertation","venue":"UCL Discovery (University College London)","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Glucocerebrosidase; Parkinson's disease; Parkinsonism; LRRK2; Neuroprotection; Penetrance; Medicine; Disease; Internal medicine; Oncology; Bioinformatics; Neuroscience; Psychology; Biology; Genetics; Phenotype","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001375415,0.0003541106,0.0004882077,0.0005168966,0.0001286609,0.0007199456,0.0002892805,0.0003604814,0.001290172],"category_scores_gemma":[0.001952349,0.0001633092,0.0007928424,0.0005571683,0.0001464233,0.000221061,0.000304955,0.000562962,0.0001627872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002334145,"about_ca_system_score_gemma":0.0004353968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006435531,"about_ca_topic_score_gemma":0.001472902,"domain_scores_codex":[0.999602,0.0001946198,0.00004386195,0.00007924873,0.00006242881,0.0000178011],"domain_scores_gemma":[0.999348,0.0003514926,0.000171434,0.00004054569,0.00005395439,0.00003452376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007633364,0.0002291668,0.6284115,0.001953281,0.003783758,0.0005068942,0.0005508695,0.005081347,0.01451712,0.003309812,0.003796122,0.3302267],"study_design_scores_gemma":[0.0007860566,0.004503622,0.9101585,0.001953367,0.008306433,0.002387807,0.0006217164,0.01966938,0.01587178,0.015548,0.0200859,0.0001073267],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9136653,0.06754854,0.01172587,0.002452017,0.0001689515,0.0001950011,0.001069379,0.00006556508,0.0031094],"genre_scores_gemma":[0.9669917,0.01727946,0.01274677,0.0002335278,0.000150672,0.000120704,0.0005492436,0.00001695115,0.001911016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001375415,"threshold_uncertainty_score":0.007274032,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01041445509408361,"score_gpt":0.2301793540646467,"score_spread":0.219764898970563,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}