{"id":"W2790637625","doi":"10.1128/mbio.02393-17","title":"The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells","year":2018,"lang":"en","type":"article","venue":"mBio","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Agence Nationale de la Recherche","keywords":"DNA damage; Biology; DNA; DNA repair; Nonribosomal peptide; Escherichia coli; DNA replication; Fanconi anemia; FANCD2; Polyketide; Carcinogenesis; Genome instability; Gene; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002195703,0.0004569252,0.0002651304,0.000203331,0.0001533564,0.0003876854,0.000258726,0.0003678239,0.001615836],"category_scores_gemma":[0.0001587276,0.0002034838,0.0002702276,0.000159269,0.0001808306,0.0001704211,0.0002870607,0.0005752317,0.0006328817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000384989,"about_ca_system_score_gemma":0.0001562503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007839324,"about_ca_topic_score_gemma":0.0004363007,"domain_scores_codex":[0.9996873,0.00006631972,0.0000359714,0.00006531189,0.00008704355,0.00005809575],"domain_scores_gemma":[0.9997757,0.00006124948,0.00003920232,0.00005363644,0.00003005804,0.0000401805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000480149,0.000025065,0.0001322294,0.00001843818,0.000004307425,0.00003961416,0.00001999679,0.00003042411,0.999369,0.00006655631,0.00001885286,0.0002276027],"study_design_scores_gemma":[0.000008971486,0.0002322904,0.002062273,0.000005487068,0.000007082993,0.0001318613,0.00002490973,0.001026285,0.9955477,0.00003117614,0.0009188401,0.000003093428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931638,0.0008005933,0.003541757,0.00005731896,0.0000639627,0.00005702627,0.0005349626,0.0001065447,0.001674086],"genre_scores_gemma":[0.9908716,0.0004853912,0.002903347,0.00006411888,0.00001486841,0.00006110668,0.001590767,0.00002634598,0.003982478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001615836,"threshold_uncertainty_score":0.005405486,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007274938838213673,"score_gpt":0.2530431192764734,"score_spread":0.2457681804382598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}