{"id":"W2790637625","doi":"10.1128/mbio.02393-17","title":"The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells","year":2018,"lang":"en","type":"article","venue":"mBio","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":257,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Agence Nationale de la Recherche","keywords":"DNA damage; Biology; DNA; DNA repair; Nonribosomal peptide; Escherichia coli; DNA replication; Fanconi anemia; FANCD2; Polyketide; Carcinogenesis; Genome instability; Gene; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002292085,0.0001263734,0.00009011727,0.00002369927,0.0001184618,0.00008504657,0.0002252098,0.0002391339,0.00004681275],"category_scores_gemma":[0.00005355819,0.00009843864,0.00005443252,0.00008760342,0.0001725485,0.000003017783,0.0001097563,0.0001329273,0.00006996054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001840756,"about_ca_system_score_gemma":0.00004912505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003612186,"about_ca_topic_score_gemma":0.000671603,"domain_scores_codex":[0.9991274,0.00006386083,0.0001848756,0.0002709389,0.00007577881,0.0002771032],"domain_scores_gemma":[0.999469,0.00001633113,0.00005303484,0.0003385612,0.00007194471,0.00005112626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008781193,0.00002929268,0.001046818,0.000003318221,0.00001758393,0.000002868128,0.00006609083,0.00000364354,0.9963046,0.00004125291,0.001340752,0.001055996],"study_design_scores_gemma":[0.0004683458,0.0002511212,0.001847329,0.000005818621,0.000003673721,0.000004745732,0.00003150459,0.0001020499,0.9626533,0.0001039153,0.0344023,0.0001258365],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976456,0.0001433359,0.0001987372,0.00007837565,0.0004236835,0.000193227,0.000009110238,0.00002012542,0.001287801],"genre_scores_gemma":[0.997317,0.00004948036,0.0002617435,0.0002506808,0.0002910539,0.00002144898,0.00002293202,0.00002134871,0.001764379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03365121,"threshold_uncertainty_score":0.4014211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007274938838213673,"score_gpt":0.2530431192764734,"score_spread":0.2457681804382598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}