{"id":"W2790692653","doi":"10.1093/jcag/gwy008.170","title":"A169 FLUORESCENT LABELING OF THE HCV HELICASE TO MONITOR NUCLEIC ACID UNWINDING BY FRET","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; University of Ottawa; McGill University","funders":"","keywords":"Helicase; Förster resonance energy transfer; Nucleic acid; Fluorophore; Biochemistry; Chemistry; RNA Helicase A; Biophysics; Amino acid; DNA; Molecular biology; Biology; RNA; Fluorescence; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000489752,0.0005026423,0.0003857217,0.0002504684,0.0002558551,0.000324615,0.0005861687,0.0008909812,0.001383073],"category_scores_gemma":[0.0002744238,0.000201972,0.0002827758,0.0003729346,0.0002828079,0.000399344,0.0004087133,0.0007793408,0.0005197391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005742651,"about_ca_system_score_gemma":0.0002170648,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008467449,"about_ca_topic_score_gemma":0.0008412949,"domain_scores_codex":[0.9996285,0.00006955124,0.00001714539,0.0001219666,0.00008213439,0.00008065769],"domain_scores_gemma":[0.9998699,0.00004143774,0.00002200473,0.00002406117,0.00002422128,0.00001828278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003725373,0.00002067874,0.00005228462,0.00003337718,0.000002511363,0.00003570428,0.00001771515,0.0002136941,0.9978939,0.0002836587,0.00007967595,0.001329691],"study_design_scores_gemma":[0.000006468016,0.00006137842,0.0002464067,0.000002978852,0.000002846835,0.00005894627,0.000007441512,0.003892703,0.9947456,0.00004680409,0.0009224662,0.000005845779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8775355,0.001081257,0.113048,0.000293318,0.00006179428,0.0001479518,0.0007892385,0.0007883476,0.006254533],"genre_scores_gemma":[0.9319966,0.0007362662,0.06215578,0.0001169881,0.000008614368,0.0002561574,0.0006732364,0.00008327285,0.003973004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001383073,"threshold_uncertainty_score":0.004626811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00829229990761195,"score_gpt":0.2561764236101347,"score_spread":0.2478841237025227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}