{"id":"W2790694922","doi":"10.1158/1538-7445.sabcs17-ot3-05-06","title":"Abstract OT3-05-06: EarLEE-2: A phase 3 study of ribociclib + endocrine therapy (ET) for adjuvant treatment of patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–), intermediate-risk, early breast cancer (EBC)","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Letrozole; Internal medicine; Exemestane; Anastrozole; Oncology; Tamoxifen; Breast cancer; Placebo; Adjuvant therapy; Aromatase inhibitor; Gynecology; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000418427,0.0006293181,0.001332254,0.0004864404,0.0003533379,0.00003768508,0.0003887886,0.0001319952,0.001227879],"category_scores_gemma":[0.0001169759,0.0004499843,0.0002227627,0.0007561387,0.001289647,0.000447957,0.00009896557,0.0005761079,0.00001463681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001407708,"about_ca_system_score_gemma":0.0007266153,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01633552,"about_ca_topic_score_gemma":0.001589984,"domain_scores_codex":[0.9951304,0.0004570978,0.0009048271,0.001014149,0.001390287,0.001103256],"domain_scores_gemma":[0.9936141,0.000632573,0.0007294049,0.0007091915,0.003879768,0.0004349083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1199477,0.01938352,0.3950163,0.0002967628,0.004988421,0.00002812627,0.05027655,0.000007085537,0.1199141,0.00002054446,0.0008834439,0.2892375],"study_design_scores_gemma":[0.04966172,0.0437831,0.7777028,0.0004004027,0.000130009,0.000002476986,0.002204255,0.000003333954,0.1250692,0.00004504789,0.0006171287,0.0003805078],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984402,0.001471924,0.0000403115,0.0003509059,0.0001786481,0.006297387,0.007157495,0.00005911574,0.00004223469],"genre_scores_gemma":[0.99365,0.001874066,0.0002493004,0.00004861824,0.0006985344,0.002836255,0.0002042608,0.0001822611,0.0002567038],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3826865,"threshold_uncertainty_score":0.9997952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05504354911564246,"score_gpt":0.4128187452303526,"score_spread":0.3577751961147101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}