{"id":"W2790694922","doi":"10.1158/1538-7445.sabcs17-ot3-05-06","title":"Abstract OT3-05-06: EarLEE-2: A phase 3 study of ribociclib + endocrine therapy (ET) for adjuvant treatment of patients with hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2–), intermediate-risk, early breast cancer (EBC)","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Medicine; Letrozole; Internal medicine; Exemestane; Anastrozole; Oncology; Tamoxifen; Breast cancer; Placebo; Adjuvant therapy; Aromatase inhibitor; Gynecology; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001459824,0.001017781,0.001138645,0.0002362903,0.0002770929,0.0008679376,0.0007267033,0.001147584,0.007982499],"category_scores_gemma":[0.0007844783,0.0003007881,0.001585967,0.0002583407,0.0005059039,0.0006657661,0.0002905473,0.002901233,0.0008767082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005635039,"about_ca_system_score_gemma":0.001139341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154993,"about_ca_topic_score_gemma":0.003938575,"domain_scores_codex":[0.9997497,0.0001238045,0.00001149123,0.00003921832,0.00002632669,0.00004941629],"domain_scores_gemma":[0.9995657,0.00008229261,0.00009779826,0.00003043936,0.00003341891,0.0001903639],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8976108,0.01860209,0.001923982,0.0009921805,0.001535292,0.0001142256,0.00007803249,0.0008002232,0.01756209,0.0003962947,0.007062794,0.05332191],"study_design_scores_gemma":[0.8805979,0.1104549,0.00356375,0.00005488208,0.0005703006,0.0001025845,0.00002684007,0.0005311393,0.001461904,0.0001788824,0.002435292,0.00002160988],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9696103,0.008374002,0.001276984,0.001559632,0.0005651251,0.005049292,0.005867325,0.0002956536,0.007401728],"genre_scores_gemma":[0.9655407,0.005064972,0.003497984,0.003501151,0.0004058535,0.004395816,0.006669986,0.00006147043,0.01086208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007982499,"threshold_uncertainty_score":0.02670407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05504354911564246,"score_gpt":0.4128187452303526,"score_spread":0.3577751961147101,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}