{"id":"W2790698850","doi":"10.1177/2040622318759282","title":"Interleukin 23 in the skin: role in psoriasis pathogenesis and selective interleukin 23 blockade as treatment","year":2018,"lang":"en","type":"article","venue":"Therapeutic Advances in Chronic Disease","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; Dermira; Regeneron Pharmaceuticals; Celgene; Valeant Pharmaceuticals International; Sanofi; Eli Lilly and Company; Amgen","keywords":"Psoriasis; Medicine; Pathogenesis; Interleukin 23; Interleukin 17; Immunology; Immune system; Disease; Interleukin; Plaque psoriasis; Dermatology; Cytokine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004163847,0.0003149246,0.000457575,0.0003738439,0.0001739354,0.0007025275,0.0002088887,0.0005469098,0.0009318321],"category_scores_gemma":[0.0001776479,0.00009512221,0.0002089516,0.0002646372,0.0003541901,0.000637676,0.0002814651,0.001461128,0.000400728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003478634,"about_ca_system_score_gemma":0.0003905337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002134046,"about_ca_topic_score_gemma":0.000648456,"domain_scores_codex":[0.9998776,0.00004098283,0.00001228486,0.0000132323,0.00003280978,0.00002313632],"domain_scores_gemma":[0.9999298,0.00002096114,0.00001541197,0.000002867321,0.00001378659,0.00001722405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001303541,0.0004644202,0.0009844888,0.00304912,0.00006977828,0.001212958,0.0001850277,0.0007426376,0.0622431,0.01330039,0.01330156,0.903143],"study_design_scores_gemma":[0.0008326333,0.006981004,0.007975685,0.002481937,0.0004025396,0.01338115,0.0003951232,0.001734188,0.04146999,0.01321509,0.911038,0.00009279889],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.009517182,0.9835383,0.001065366,0.002870405,0.0003196973,0.00001788325,0.00001944096,0.00002156551,0.002630088],"genre_scores_gemma":[0.06661303,0.9265357,0.001904783,0.001514663,0.001078528,0.00004668516,0.00003916473,0.000009486049,0.002257957],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0009318321,"threshold_uncertainty_score":0.003117263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01322450683493577,"score_gpt":0.2860726091938545,"score_spread":0.2728481023589187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}