{"id":"W2790700912","doi":"10.1016/j.xphs.2018.03.012","title":"Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo : Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and Mechanistic Insights","year":2018,"lang":"en","type":"article","venue":"Journal of Pharmaceutical Sciences","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"In vivo; Albumin; Extrapolation; Hepatocyte; Chemistry; In vitro; Plasma protein binding; Dissociation constant; Biophysics; Pharmacology; Free fraction; Drug; Drug metabolism; Serum albumin; Biochemistry; Metabolism; Biology; Mathematics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003447785,0.001487927,0.001228245,0.001135255,0.0002150681,0.00124944,0.00130602,0.00135538,0.000690449],"category_scores_gemma":[0.009143651,0.000428673,0.002033461,0.000718,0.0005708307,0.001333188,0.0008946072,0.001611944,0.0005077972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001247244,"about_ca_system_score_gemma":0.001310397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004202537,"about_ca_topic_score_gemma":0.001303576,"domain_scores_codex":[0.9983909,0.0007514994,0.000115628,0.0002264792,0.0003668435,0.0001486018],"domain_scores_gemma":[0.9963745,0.002227886,0.0004397061,0.0004379087,0.0004599227,0.00005997465],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.01164372,0.0007859822,0.0322316,0.002853884,0.001105267,0.001373659,0.001279502,0.4663308,0.3059211,0.02323671,0.002752753,0.1504851],"study_design_scores_gemma":[0.0001978653,0.003880368,0.01899993,0.0003087498,0.0005967511,0.001991473,0.000391689,0.7576934,0.1959671,0.01332685,0.006375363,0.0002705017],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6154923,0.01818845,0.3502405,0.001314364,0.0003345564,0.0003753394,0.001904693,0.001058302,0.01109148],"genre_scores_gemma":[0.9796593,0.00473882,0.01310506,0.000200299,0.00003866939,0.0001670385,0.0008456,0.00009893881,0.001146314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004202537,"threshold_uncertainty_score":0.01823384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0950868978918031,"score_gpt":0.3556164955580439,"score_spread":0.2605295976662408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}