{"id":"W2790707728","doi":"10.1200/jco.2018.36.6_suppl.333","title":"Loss of RSPO3 as a potential mechanism of greater invasiveness in prostate cancer.","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre; University of Toronto","funders":"","keywords":"Prostate cancer; Medicine; Downregulation and upregulation; Cancer research; Protein kinase B; PI3K/AKT/mTOR pathway; Prostate; Cancer; Signal transduction; Radiation therapy; Oncology; Internal medicine; Biology; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578862,0.0003207395,0.0001669497,0.0002956751,0.0001994644,0.0004199258,0.0003217229,0.0004802313,0.002396544],"category_scores_gemma":[0.0001143704,0.0001578095,0.0003491006,0.0002523664,0.0003285216,0.0002952419,0.0001873614,0.0008336552,0.0005210591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003169463,"about_ca_system_score_gemma":0.0003057509,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007660876,"about_ca_topic_score_gemma":0.0009920798,"domain_scores_codex":[0.9998902,0.00001259118,0.00000673559,0.0000195688,0.00004870821,0.00002205579],"domain_scores_gemma":[0.9999055,0.00001470324,0.00003376359,0.00001238074,0.00001139676,0.0000222805],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001443821,0.00003881572,0.001087274,0.00008626679,0.00001194566,0.0001450322,0.00001696134,0.00009280733,0.9951858,0.0003990094,0.0001758497,0.002615868],"study_design_scores_gemma":[0.00003214959,0.0004852006,0.02848352,0.00001579305,0.00004842471,0.001982915,0.00007437877,0.001553867,0.9582511,0.0002570213,0.008802929,0.00001267255],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838771,0.0046151,0.00614601,0.0004932779,0.00008352524,0.00008682137,0.001057179,0.0003000539,0.003340927],"genre_scores_gemma":[0.9928662,0.001251886,0.001393342,0.0001317221,0.000008819568,0.00004920413,0.0007759237,0.00002352383,0.003499386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002396544,"threshold_uncertainty_score":0.008017242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1265003753620187,"score_gpt":0.5013553112941292,"score_spread":0.3748549359321105,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}