{"id":"W2790743418","doi":"10.1097/tp.0000000000002117","title":"A Comparison of HLA Molecular Mismatch Methods to Determine HLA Immunogenicity","year":2018,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Diagnostic Services Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research; Evelyn Trust; National Institute for Health and Care Research; Academy of Medical Sciences; Research Manitoba","keywords":"Immunosuppression; Human leukocyte antigen; Immunogenicity; Medicine; Hazard ratio; Correlation; Internal medicine; Transplantation; Kidney transplantation; Amino acid; Immunology; Antibody; Oncology; Biology; Antigen; Genetics; Confidence interval; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01276227,0.0008028735,0.0005018665,0.002843897,0.0001642683,0.0008044526,0.0005341086,0.0006912516,0.001659034],"category_scores_gemma":[0.02247608,0.0003178544,0.0006132983,0.0009639426,0.0002959958,0.0008049871,0.0009151716,0.0006801005,0.0006277263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004364419,"about_ca_system_score_gemma":0.0003098604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003941012,"about_ca_topic_score_gemma":0.0004677726,"domain_scores_codex":[0.9921977,0.005027608,0.0004027758,0.0006182124,0.001567862,0.0001858186],"domain_scores_gemma":[0.9793066,0.01360006,0.002036926,0.001343502,0.003240549,0.0004724526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01224799,0.000613836,0.5285016,0.0008844706,0.00202527,0.0001452215,0.0004011449,0.008505364,0.05377477,0.003387194,0.001521233,0.3879918],"study_design_scores_gemma":[0.0008853771,0.01722451,0.6082681,0.0004271066,0.001876866,0.00407734,0.0008035499,0.2468075,0.09639713,0.007932969,0.01488108,0.0004184352],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8161851,0.01488092,0.1611946,0.0003229373,0.0004285093,0.0005999337,0.001103298,0.0004686569,0.004816123],"genre_scores_gemma":[0.9036944,0.002506438,0.09095985,0.0001514238,0.0001169353,0.0004949562,0.0006554995,0.00009127741,0.001329246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01276227,"threshold_uncertainty_score":0.06749409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0574301441800248,"score_gpt":0.4365820358412855,"score_spread":0.3791518916612607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}