{"id":"W2790743418","doi":"10.1097/tp.0000000000002117","title":"A Comparison of HLA Molecular Mismatch Methods to Determine HLA Immunogenicity","year":2018,"lang":"en","type":"article","venue":"Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"Diagnostic Services Manitoba; University of Manitoba","funders":"Canadian Institutes of Health Research; Evelyn Trust; National Institute for Health and Care Research; Academy of Medical Sciences; Research Manitoba","keywords":"Immunosuppression; Human leukocyte antigen; Immunogenicity; Medicine; Hazard ratio; Correlation; Internal medicine; Transplantation; Kidney transplantation; Amino acid; Immunology; Antibody; Oncology; Biology; Antigen; Genetics; Confidence interval; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001507028,0.0001509465,0.0003708288,0.0001296797,0.00004893736,0.000008230816,0.00007157233,0.00007089567,0.0001332627],"category_scores_gemma":[0.00001015114,0.0001289451,0.0001216235,0.000237998,0.00004925325,0.00005438218,0.000003620801,0.00006818893,0.00005890376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002616209,"about_ca_system_score_gemma":0.00003203993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001104835,"about_ca_topic_score_gemma":0.00002775948,"domain_scores_codex":[0.9988769,0.00008218826,0.0004225352,0.0002101796,0.0002349102,0.0001733383],"domain_scores_gemma":[0.999375,0.00008563707,0.00009152053,0.0002013731,0.0001323898,0.0001140073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002224328,0.0003393615,0.05223184,0.0006928861,0.0002956701,0.00007283958,0.005137834,0.00004091643,0.9200323,0.0002469599,0.00001261975,0.01867245],"study_design_scores_gemma":[0.002560893,0.0007821003,0.1180538,0.000297365,0.0005434499,0.00009983054,0.00006444945,0.0003844508,0.8769149,0.0000598422,0.0001211017,0.0001177617],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8050442,0.00008615078,0.1925174,0.000130911,0.00009773781,0.0003774056,0.00003690349,0.00003765351,0.001671636],"genre_scores_gemma":[0.8870494,0.00004638247,0.1123785,0.0002033857,0.00002724258,0.00001770358,0.0001352269,0.00001720785,0.0001249499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08200524,"threshold_uncertainty_score":0.5258228,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0574301441800248,"score_gpt":0.4365820358412855,"score_spread":0.3791518916612607,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}