{"id":"W2790746318","doi":"10.1186/s13195-018-0336-4","title":"Assessment of kallikrein 6 as a cross-sectional and longitudinal biomarker for Alzheimer’s disease","year":2018,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Skånes universitetssjukhus; Stiftelsen Olle Engkvist Byggmästare; Demensförbundet; Alzheimer's Association","keywords":"Geriatric psychiatry; Biomarker; Medicine; Neurology; Cross-sectional study; Disease; Kallikrein; Internal medicine; Gerontology; Psychiatry; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001407664,0.000216328,0.0003266786,0.0003039014,0.0004128937,0.00009914202,0.0001804038,0.0001153078,0.0009965701],"category_scores_gemma":[0.0001216402,0.0001799357,0.0001975081,0.0003787714,0.001079097,0.0001926144,0.00008409843,0.0001849152,0.00002704298],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000327077,"about_ca_system_score_gemma":0.0006342599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003388303,"about_ca_topic_score_gemma":0.00002279516,"domain_scores_codex":[0.9973428,0.000132572,0.0004259119,0.0005733517,0.0009544695,0.0005709245],"domain_scores_gemma":[0.9974133,0.000452759,0.00009993067,0.0004676376,0.001116528,0.0004498413],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003059,0.0004770157,0.9555945,0.00002854188,0.002020669,0.00001454304,0.0001899697,9.498929e-7,0.00454306,0.00429191,0.001831081,0.02794879],"study_design_scores_gemma":[0.002975769,0.001465897,0.9695185,0.00004629772,0.0001542559,0.00001672002,0.00002682138,0.00124687,0.004904285,0.002420431,0.01705043,0.0001736641],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9599931,0.03465108,0.0003275246,0.001389173,0.0002481472,0.001798731,0.00006148015,0.00005754224,0.001473177],"genre_scores_gemma":[0.9964715,0.0008283228,0.001062432,0.0002244505,0.0005913319,0.0002032588,0.00008232784,0.00005014234,0.0004862419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03647835,"threshold_uncertainty_score":0.9999167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2653224240577184,"score_gpt":0.503435559908117,"score_spread":0.2381131358503985,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}