{"id":"W2790803800","doi":"10.1111/cas.13537","title":"NRF2 addiction in cancer cells","year":2018,"lang":"en","type":"review","venue":"Cancer Science","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":273,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Japan Society for the Promotion of Science; Princess Takamatsu Cancer Research Fund; Mitsubishi Foundation; Uehara Memorial Foundation; Naito Foundation","keywords":"Cancer; Cancer cell; Cancer research; Cytoprotection; KEAP1; Oxidative stress; Reprogramming; Mechanism (biology); Medicine; Biology; Bioinformatics; Cell; Gene; Internal medicine; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002411481,0.0002690431,0.0004618835,0.0001197724,0.00009292571,0.00004381666,0.0007806199,0.0002157758,0.0000787141],"category_scores_gemma":[0.00004058802,0.0002368381,0.0001401684,0.0004653696,0.0006776746,0.000007451534,0.0002440888,0.0001663016,0.00002839905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002293968,"about_ca_system_score_gemma":0.001379164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001288236,"about_ca_topic_score_gemma":0.0002304667,"domain_scores_codex":[0.9981939,0.00003783097,0.0003041087,0.0008663582,0.000180036,0.0004178312],"domain_scores_gemma":[0.999046,0.000008014591,0.000218783,0.000471349,0.0001359996,0.0001198015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000128065,0.00005174702,0.00005259594,0.001496715,0.00005241094,0.00000213905,0.00006592427,0.00001448264,0.05826988,0.00001256421,0.01221625,0.9277525],"study_design_scores_gemma":[0.00008846303,0.00003731357,0.00002253365,0.001507357,0.00004496886,0.000001526734,0.000004921517,0.000004787655,0.05156716,0.000008834515,0.9464225,0.0002897022],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009570763,0.9963316,0.00004044183,0.00001085201,0.001319313,0.0003208843,0.0001836347,0.000006844977,0.000829377],"genre_scores_gemma":[0.0004730266,0.9974928,0.0001144149,0.00009267804,0.0009494849,0.000266276,0.00004159797,0.00002443739,0.0005452929],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9342062,"threshold_uncertainty_score":0.9657977,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.042972263018152,"score_gpt":0.3742194737529344,"score_spread":0.3312472107347824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}