{"id":"W2790803800","doi":"10.1111/cas.13537","title":"NRF2 addiction in cancer cells","year":2018,"lang":"en","type":"review","venue":"Cancer Science","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":273,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"Japan Society for the Promotion of Science; Princess Takamatsu Cancer Research Fund; Mitsubishi Foundation; Uehara Memorial Foundation; Naito Foundation","keywords":"Cancer; Cancer cell; Cancer research; Cytoprotection; KEAP1; Oxidative stress; Reprogramming; Mechanism (biology); Medicine; Biology; Bioinformatics; Cell; Gene; Internal medicine; Transcription factor; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001601866,0.0002706528,0.0003171336,0.0003364026,0.0002786047,0.0005025927,0.0002449149,0.0004295594,0.002095666],"category_scores_gemma":[0.0001239795,0.00009656531,0.0002597718,0.0004800755,0.0001879669,0.0004319649,0.0003519749,0.0005767102,0.001178043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003485094,"about_ca_system_score_gemma":0.0002824614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004249026,"about_ca_topic_score_gemma":0.0007019764,"domain_scores_codex":[0.9998844,0.00002189918,0.00001078498,0.0000296256,0.00003556646,0.00001785686],"domain_scores_gemma":[0.9999564,0.000007566512,0.000009436984,0.000004822446,0.00001523622,0.000006558401],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004506612,0.0001156464,0.001390671,0.006372287,0.0001232129,0.001849986,0.0003726329,0.0005966924,0.7073696,0.02092213,0.0148419,0.2455946],"study_design_scores_gemma":[0.00003358365,0.0002894586,0.003967131,0.0003417528,0.0001090637,0.003845539,0.0002256004,0.0007192913,0.2207616,0.005381379,0.7642887,0.00003693821],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.1384676,0.7788876,0.01862321,0.005341972,0.001499926,0.0001538089,0.002245976,0.000551452,0.05422851],"genre_scores_gemma":[0.4946291,0.4439251,0.00659857,0.002274929,0.0003883245,0.0002394093,0.003060473,0.00007707695,0.04880703],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002095666,"threshold_uncertainty_score":0.007010698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.042972263018152,"score_gpt":0.3742194737529344,"score_spread":0.3312472107347824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}