{"id":"W2790811214","doi":"10.1093/jcag/gwy008.314","title":"A313 MUCOSAL PROTEASES FROM IBS PATIENTS PRODUCE LONG TERM HYPEREXCITABILITY IN NOCICEPTIVE DRG NEURONS BY ACTIVATING NOVEL INTRACELLULAR SIGNALING PATHWAYS","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"","keywords":"Rheobase; Proteases; Nociception; Irritable bowel syndrome; Receptor; Pharmacology; Medicine; Neuroscience; Chemistry; Internal medicine; Cell biology; Biology; Electrophysiology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001341306,0.0001933739,0.0004446816,0.0001799399,0.0002285284,0.00001595359,0.0004451745,0.0002716392,0.0001100594],"category_scores_gemma":[0.001558886,0.0001730906,0.000140068,0.0001688534,0.0001872472,0.0002384626,0.00006625641,0.001028683,0.000005465348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001756619,"about_ca_system_score_gemma":0.0003505306,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002606478,"about_ca_topic_score_gemma":0.06780307,"domain_scores_codex":[0.9966919,0.001344891,0.0008915648,0.000243719,0.0002964236,0.0005314582],"domain_scores_gemma":[0.9964342,0.0004160497,0.002017705,0.0001742107,0.0007050889,0.0002527742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004109951,0.0002663049,0.9211997,0.00001196546,0.0001659303,0.000004314532,0.0009995551,0.0003565029,0.07547955,0.00000226164,0.000619184,0.0004836846],"study_design_scores_gemma":[0.003911337,0.0008403825,0.970375,0.0000795449,0.0001064913,0.00001282044,0.0002190452,0.0003899094,0.02304138,0.00004814195,0.0008338755,0.0001420763],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954908,0.00002056193,0.0001374777,0.001921059,0.00150414,0.0005105455,0.000376701,0.00000643479,0.00003222619],"genre_scores_gemma":[0.9983965,0.00000389523,0.0002154866,0.0009072231,0.0003911222,0.00001042461,0.00001536227,0.00002060844,0.00003943681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0651966,"threshold_uncertainty_score":0.9492071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03933322030337916,"score_gpt":0.3101808434119909,"score_spread":0.2708476231086118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}