{"id":"W2790811214","doi":"10.1093/jcag/gwy008.314","title":"A313 MUCOSAL PROTEASES FROM IBS PATIENTS PRODUCE LONG TERM HYPEREXCITABILITY IN NOCICEPTIVE DRG NEURONS BY ACTIVATING NOVEL INTRACELLULAR SIGNALING PATHWAYS","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Advanced Drug Delivery Systems","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston General Hospital; Queen's University","funders":"","keywords":"Rheobase; Proteases; Nociception; Irritable bowel syndrome; Receptor; Pharmacology; Medicine; Neuroscience; Chemistry; Internal medicine; Cell biology; Biology; Electrophysiology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007948087,0.0002653752,0.0003572193,0.0001635682,0.0001670206,0.0002097849,0.0001108588,0.0003677696,0.003718215],"category_scores_gemma":[0.00009543639,0.0001318688,0.0004848819,0.0001458357,0.0001469012,0.0001677712,0.0001931132,0.0006419304,0.0006560173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001375952,"about_ca_system_score_gemma":0.0001329752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006880924,"about_ca_topic_score_gemma":0.0007431719,"domain_scores_codex":[0.9998915,0.00001020725,0.000009859486,0.00002057562,0.00002683183,0.00004095441],"domain_scores_gemma":[0.9999576,0.000004722327,0.0000103669,0.000003738376,0.000006306805,0.00001727009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004731894,0.00004247368,0.0007131416,0.00007009575,0.00001169726,0.0002290456,0.00001428397,0.00001842752,0.9966559,0.00001805946,0.0001059685,0.001647787],"study_design_scores_gemma":[0.0002631411,0.004773696,0.2822803,0.00006663834,0.0001175247,0.006330709,0.0003986247,0.001472667,0.6997834,0.0002810193,0.004204874,0.00002741227],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952723,0.001785139,0.0007003489,0.0001776159,0.00005213309,0.00002288342,0.0006903632,0.00003873175,0.001260527],"genre_scores_gemma":[0.994164,0.001363609,0.001110207,0.0002058005,0.00002346606,0.00006920574,0.0009823019,0.00001136633,0.002070071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003718215,"threshold_uncertainty_score":0.01243871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03933322030337916,"score_gpt":0.3101808434119909,"score_spread":0.2708476231086118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}