{"id":"W2790823556","doi":"10.1101/251991","title":"BMP Signaling Downstream of the Highwire E3 Ligase Sensitizes Nociceptors","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of General Medical Sciences; Japan Society for the Promotion of Science; National Institutes of Health; Uehara Memorial Foundation","keywords":"Nociceptor; Nociception; Cell biology; Signal transduction; Hyperalgesia; Noxious stimulus; Phenotype; Chemistry; Neuroscience; Biology; Receptor; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001097106,0.0004517203,0.0003000036,0.00021823,0.0001668086,0.0003406509,0.0002568955,0.0003684168,0.002306261],"category_scores_gemma":[0.00009053273,0.0002261351,0.0003793887,0.0001027952,0.0003170025,0.0002424977,0.0004277499,0.0009837919,0.0005231278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003695278,"about_ca_system_score_gemma":0.0001292002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003570013,"about_ca_topic_score_gemma":0.0004835046,"domain_scores_codex":[0.9998349,0.00001886283,0.00001538203,0.00002842851,0.00005549125,0.00004691627],"domain_scores_gemma":[0.9998853,0.00001508576,0.00003234233,0.00001519002,0.00001309589,0.00003893369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002190325,0.000005091567,0.00006762954,0.00001272971,0.000002692166,0.00002243608,0.000001902982,0.00002372244,0.9995963,0.00003645168,0.0000115902,0.0001974389],"study_design_scores_gemma":[0.00000444495,0.00003686151,0.002416985,0.000002502742,0.000005444841,0.00009429197,0.00001075744,0.0005894448,0.9962686,0.00002849583,0.0005401722,0.000002014084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907465,0.0008521367,0.006125884,0.000146567,0.00003492111,0.00003387493,0.0003139997,0.0001284733,0.001617611],"genre_scores_gemma":[0.9938792,0.0003601803,0.00257833,0.00008242014,0.000006610469,0.00002759776,0.0002732645,0.00002543152,0.002766918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002306261,"threshold_uncertainty_score":0.007715166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01216263308625691,"score_gpt":0.2239760198050683,"score_spread":0.2118133867188114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}