{"id":"W2790859977","doi":"10.1002/jsp2.1008","title":"Link N as a therapeutic agent for discogenic pain","year":2018,"lang":"en","type":"article","venue":"JOR Spine","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; AOSpine; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Nerve growth factor; Tropomyosin receptor kinase A; Neurotrophin; Tropomyosin receptor kinase B; Neurotrophic factors; Medicine; Brain-derived neurotrophic factor; Proinflammatory cytokine; Substance P; Tumor necrosis factor alpha; Hyperalgesia; Nociception; Internal medicine; Low-affinity nerve growth factor receptor; Endocrinology; Receptor; Inflammation; Neuropeptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000239236,0.0001223012,0.0002416906,0.00006466741,0.00005029973,0.000009286624,0.00008309796,0.00008074497,0.00096838],"category_scores_gemma":[0.0002657633,0.00008699959,0.0001888262,0.00009170375,0.00008302323,0.00003695142,0.00002944929,0.0000814609,0.0005117206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003142023,"about_ca_system_score_gemma":0.00004735784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001761515,"about_ca_topic_score_gemma":0.00002123871,"domain_scores_codex":[0.9991938,0.00003066262,0.0002096771,0.0002210302,0.00009383568,0.0002509451],"domain_scores_gemma":[0.9995024,0.000007779148,0.0000492398,0.0002784674,0.00008266461,0.00007941817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000254856,0.0005585043,0.001313786,0.0002216642,0.0003891954,0.00008394897,0.0004737625,1.995881e-7,0.5919042,0.005205065,0.04228634,0.3573085],"study_design_scores_gemma":[0.009783909,0.04614238,0.1403208,0.000464512,0.0007263121,0.0003317588,0.0003018492,0.007776175,0.1784802,0.005479402,0.6094418,0.000750972],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8268127,0.002362222,0.1071747,0.04529026,0.001465578,0.002000101,0.00002294218,0.0002581587,0.01461336],"genre_scores_gemma":[0.9580271,0.00003302909,0.004997717,0.01907142,0.001636171,0.0001033355,0.00003882193,0.00003275049,0.01605962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5671554,"threshold_uncertainty_score":0.9999449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03887429499949197,"score_gpt":0.3537504459793407,"score_spread":0.3148761509798487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}