{"id":"W2790859977","doi":"10.1002/jsp2.1008","title":"Link N as a therapeutic agent for discogenic pain","year":2018,"lang":"en","type":"article","venue":"JOR Spine","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; AOSpine; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Nerve growth factor; Tropomyosin receptor kinase A; Neurotrophin; Tropomyosin receptor kinase B; Neurotrophic factors; Medicine; Brain-derived neurotrophic factor; Proinflammatory cytokine; Substance P; Tumor necrosis factor alpha; Hyperalgesia; Nociception; Internal medicine; Low-affinity nerve growth factor receptor; Endocrinology; Receptor; Inflammation; Neuropeptide","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009275867,0.0002653433,0.0002245801,0.0003628942,0.0001447039,0.0001873396,0.0001738844,0.0003645266,0.001816019],"category_scores_gemma":[0.00008629969,0.00005631311,0.000195097,0.0001649669,0.0001499129,0.0001830314,0.0001452943,0.0003648159,0.0002493019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001221781,"about_ca_system_score_gemma":0.0001623531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003396313,"about_ca_topic_score_gemma":0.00082757,"domain_scores_codex":[0.9999498,0.00001261145,0.000003811353,0.000008581451,0.00001536649,0.000009823352],"domain_scores_gemma":[0.9999727,0.000007733614,0.000007356951,0.000001935896,0.000004216486,0.000006083373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001684716,0.0006753246,0.0003736667,0.001385837,0.00004475039,0.0005545343,0.00006496289,0.0001436463,0.9397856,0.0003917089,0.000422484,0.05447285],"study_design_scores_gemma":[0.0009167703,0.02254087,0.01479851,0.0003847868,0.0004064969,0.004088994,0.0002114243,0.001044975,0.8751072,0.0005419718,0.07991383,0.00004412897],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8033577,0.1787654,0.005581733,0.0004327633,0.0003344611,0.0002157097,0.000346172,0.0001066481,0.01085944],"genre_scores_gemma":[0.9116691,0.07595459,0.003787944,0.0003885898,0.0001363819,0.0001483971,0.0003956436,0.00001584024,0.007503416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001816019,"threshold_uncertainty_score":0.006075144,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03887429499949197,"score_gpt":0.3537504459793407,"score_spread":0.3148761509798487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}