{"id":"W2790865211","doi":"10.1016/j.freeradbiomed.2018.02.034","title":"FOXO1 cysteine-612 mediates stimulatory effects of the coregulators CBP and PGC1α on FOXO1 basal transcriptional activity","year":2018,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"FOXO transcription factor regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"FOXO1; Transactivation; Transcription factor; Promoter; Chemistry; Biology; Gene expression; Molecular biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002197082,0.0001833752,0.0002583429,0.00005471492,0.0001239563,0.000002440124,0.0001544831,0.0003176631,0.00002831127],"category_scores_gemma":[0.000401359,0.000115579,0.00005879403,0.00007701107,0.002501463,0.000005592539,0.00004513762,0.0001413781,0.0000011968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001004858,"about_ca_system_score_gemma":0.00004491628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002524577,"about_ca_topic_score_gemma":0.00004903036,"domain_scores_codex":[0.9989402,0.0001709804,0.0002025245,0.0003422674,0.0001474674,0.0001965603],"domain_scores_gemma":[0.9992768,0.0001442012,0.00008809027,0.000301666,0.00005459712,0.0001346944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000379393,0.00005890242,0.01328155,0.00007051379,0.00007352235,7.240248e-7,0.00008301282,0.000001021458,0.9793617,0.00286614,0.001681198,0.002142372],"study_design_scores_gemma":[0.004672557,0.004106298,0.6373133,0.0001458133,0.0001138698,0.00002073044,0.00001514904,0.0001485216,0.338852,0.002644276,0.01175004,0.0002174985],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945605,0.001651218,0.0008310153,0.001790166,0.0007184649,0.0002643864,0.00003462172,0.00001308019,0.0001365507],"genre_scores_gemma":[0.998481,0.0001333203,0.00006760709,0.0005726885,0.0005933113,0.0000102649,0.0000497741,0.0000120932,0.00007989098],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6405097,"threshold_uncertainty_score":0.9216744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007482862666547922,"score_gpt":0.2533961683745938,"score_spread":0.2459133057080459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}