{"id":"W2790865280","doi":"10.1200/jco.2018.36.6_suppl.tps406","title":"Intergroup study EORTC-1532-gucg: A phase 2 randomized open-label study of oral darolutamide (ODM-201) vs. androgen deprivation therapy (ADT) with LHRH agonists or antagonist in men with hormone naive prostate cancer (PCa).","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"","keywords":"Medicine; Tolerability; Bicalutamide; Androgen deprivation therapy; Internal medicine; Endocrinology; Leuprorelin; Testosterone (patch); Clinical endpoint; Antagonist; Androgen receptor; Prostate cancer; Oncology; Urology; Adverse effect; Hormone; Randomized controlled trial; Cancer; Luteinizing hormone; Gonadotropin-releasing hormone; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003008752,0.003069611,0.003176855,0.0008527949,0.0005686786,0.001194926,0.001703384,0.003282468,0.01509024],"category_scores_gemma":[0.002164475,0.0009945617,0.002141237,0.0007983997,0.001612118,0.001263499,0.0006017071,0.003764707,0.0027432],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001616113,"about_ca_system_score_gemma":0.002478708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002569622,"about_ca_topic_score_gemma":0.007300887,"domain_scores_codex":[0.9988864,0.0006999732,0.00003912575,0.000150659,0.00007108045,0.0001526811],"domain_scores_gemma":[0.9990158,0.0001951887,0.0002190861,0.00008386945,0.00006305203,0.0004229929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9632891,0.01437673,0.0008666976,0.000641653,0.0006818704,0.00005868324,0.00005779439,0.000428515,0.003760183,0.0002148606,0.003831465,0.01179238],"study_design_scores_gemma":[0.9541965,0.04265977,0.001163328,0.00002186333,0.0002110375,0.00003191911,0.00001474216,0.000219509,0.0002136802,0.0001086614,0.001143083,0.00001581511],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9251205,0.007924751,0.001553025,0.002970849,0.001777499,0.03793734,0.01374825,0.0006644364,0.008303195],"genre_scores_gemma":[0.8998246,0.004561145,0.005866149,0.008069999,0.001469752,0.0497781,0.01315887,0.0002548838,0.01701651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01509024,"threshold_uncertainty_score":0.05048186,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1541366464985643,"score_gpt":0.5221006580994223,"score_spread":0.367964011600858,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}