{"id":"W2790874700","doi":"10.1093/jcag/gwy008.209","title":"A208 SHP-2 PHOSPHATASE PREVENTS SENESCENCE IN NORMAL AND TUMOR INTESTINAL EPITHELIAL CELLS","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Biology; Gene silencing; Protein tyrosine phosphatase; Cell biology; Cell growth; Wnt signaling pathway; Cell cycle; Carcinogenesis; Cancer research; Phosphatase; Senescence; Signal transduction; Molecular biology; Cell; Phosphorylation; Cancer; Biochemistry; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002077765,0.0004178685,0.0003784569,0.0002903944,0.0001355703,0.0003309563,0.0002427838,0.0002912965,0.001962546],"category_scores_gemma":[0.0001210591,0.0001923006,0.0003246116,0.0002374161,0.0002444229,0.0002290516,0.0002592539,0.0008655182,0.0003761682],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002298247,"about_ca_system_score_gemma":0.0003357929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007678502,"about_ca_topic_score_gemma":0.001162676,"domain_scores_codex":[0.9998078,0.00003035025,0.00002476626,0.00003905159,0.00005349905,0.00004459067],"domain_scores_gemma":[0.9999001,0.0000158365,0.00002337791,0.00001834304,0.0000109444,0.00003135206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002657248,0.0001205096,0.0001085052,0.00006619227,0.000009507207,0.00004853799,0.00001475094,0.00007437691,0.9974293,0.0001009079,0.0001231187,0.001638483],"study_design_scores_gemma":[0.00006817956,0.001383002,0.002858547,0.00001285785,0.00002651594,0.0002376122,0.00003026012,0.001061433,0.9889786,0.00006002159,0.005278104,0.000005019765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99016,0.003174379,0.002617914,0.0001655118,0.0001176788,0.00007117674,0.0008460023,0.0002490596,0.002598292],"genre_scores_gemma":[0.9908128,0.001546836,0.001465572,0.0000705163,0.00001430964,0.00007414159,0.001177888,0.00002848548,0.00480942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001962546,"threshold_uncertainty_score":0.006565332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004492730895133087,"score_gpt":0.2089644906708804,"score_spread":0.2044717597757473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}