{"id":"W2790876819","doi":"10.1158/1538-7445.sabcs17-p2-10-02","title":"Abstract P2-10-02: Basal biomarkers nestin and INPP4b predict gemcitabine benefit in metastatic breast cancer: Results from the phase III SBG0102 clinical trial","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Gemcitabine; Breast cancer; Medicine; Oncology; Internal medicine; Nestin; Metastatic breast cancer; Docetaxel; Capecitabine; Eribulin; Immunohistochemistry; Tissue microarray; Predictive marker; Triple-negative breast cancer; Cancer; Biology; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003426051,0.001262549,0.001737077,0.0002025933,0.0002359733,0.001209052,0.0005907501,0.001081114,0.005500928],"category_scores_gemma":[0.002507052,0.0003482435,0.002083761,0.0002991522,0.0006090515,0.0006069202,0.0003831126,0.002244376,0.001230521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005467651,"about_ca_system_score_gemma":0.001151277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005983858,"about_ca_topic_score_gemma":0.001301767,"domain_scores_codex":[0.9991296,0.0005626965,0.00004753213,0.0001332454,0.00005979249,0.00006720426],"domain_scores_gemma":[0.9979342,0.0007782383,0.0003727444,0.0001815344,0.0001374148,0.0005959576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9466276,0.003342056,0.0163794,0.0006422953,0.002373247,0.00008243546,0.0000615192,0.001088783,0.006128307,0.00009755659,0.003072597,0.02010437],"study_design_scores_gemma":[0.720479,0.1719334,0.08794632,0.0001875758,0.00600482,0.0003822836,0.00008340414,0.004324425,0.003992856,0.0008197756,0.003774831,0.00007132676],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863534,0.003678713,0.0006231614,0.0009052836,0.0001537686,0.001286085,0.004458454,0.0000858665,0.002455383],"genre_scores_gemma":[0.9821714,0.001235646,0.001216823,0.0008172861,0.0002320538,0.001394953,0.009781132,0.00004566971,0.003105025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005500928,"threshold_uncertainty_score":0.01840246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1138208310218671,"score_gpt":0.4577968833309308,"score_spread":0.3439760523090637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}