{"id":"W2790891082","doi":"10.1523/eneuro.0396-17.2018","title":"Atypical Localization and Dissociation between Glucose Uptake and Amyloid Deposition in Cognitively Normal APOE*E4 Homozygotic Elders Compared with Patients with Late-Onset Alzheimer’s Disease","year":2018,"lang":"en","type":"article","venue":"eNeuro","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; National Institutes of Health; Servier; Eisai; Northern California Institute for Research and Education; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Biogen; National Institute on Aging; Alzheimer's Association; Eli Lilly and Company; Bristol-Myers Squibb; University of Southern California; U.S. Department of Veterans Affairs; Foundation for the National Institutes of Health","keywords":"Apolipoprotein E; Posterior cingulate; Neuroimaging; Putamen; Pittsburgh compound B; Alzheimer's disease; Neuroscience; Alzheimer's Disease Neuroimaging Initiative; Medicine; Postmortem studies; Psychology; Disease; Pathology; Cognition","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004805979,0.0005568927,0.0005431274,0.002068222,0.0003865523,0.0007167701,0.0002498516,0.0005528987,0.001688683],"category_scores_gemma":[0.001741391,0.0003208774,0.0002913312,0.0006436657,0.0005078587,0.0005401302,0.0004705566,0.0003062139,0.0003796168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002273683,"about_ca_system_score_gemma":0.000160197,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002294265,"about_ca_topic_score_gemma":0.002344286,"domain_scores_codex":[0.9997701,0.00003889603,0.00004190026,0.00005745128,0.00004357839,0.00004799428],"domain_scores_gemma":[0.9991948,0.0001859973,0.0002915254,0.00005662288,0.0000807726,0.0001903748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003869925,0.0001602287,0.9462395,0.00004912748,0.0001420566,0.008574467,0.001053423,0.00009054274,0.0302328,0.0001362792,0.0002243704,0.009227335],"study_design_scores_gemma":[0.00002239861,0.0001887251,0.9931116,0.000004194502,0.00002763892,0.00539639,0.0002917297,0.0001129797,0.0005975883,0.0001432901,0.00009589786,0.000007643809],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996145,0.00006992769,0.00004061139,0.00001410994,0.000003162575,0.00000139179,0.00003134305,0.000002781148,0.0002220613],"genre_scores_gemma":[0.9996327,0.00005574952,0.00006195842,0.00002207755,0.000009337119,0.000002258189,0.00008756105,0.00000371241,0.0001246913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002294265,"threshold_uncertainty_score":0.005649209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01861331201841872,"score_gpt":0.2683162025086324,"score_spread":0.2497028904902136,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}