{"id":"W2790900135","doi":"10.1371/journal.pone.0193032","title":"Endothelial mineralocorticoid receptor ablation does not alter blood pressure, kidney function or renal vessel contractility","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Eye Institute; Fonden til Lægevidenskabens Fremme; H. Lundbeck A/S; University of California, San Francisco; Novo Nordisk Fonden; Canadian Institutes of Health Research; A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal; Danmarks Frie Forskningsfond; Novo Nordisk; Hjerteforeningen; Syddansk Universitet; Lundbeckfonden; Carlsbergfondet; Deutsches Krebsforschungszentrum; Sundhed og Sygdom, Det Frie Forskningsråd; E-Rare","keywords":"Endocrinology; Internal medicine; Aldosterone; Kidney; Mineralocorticoid receptor; Renal function; Mineralocorticoid; Afferent arterioles; Blood pressure; Renin–angiotensin system; Medicine; Excretion; Renal blood flow; Urinary system; Vasoconstriction","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002978832,0.000354595,0.0007068241,0.0002962123,0.0001807688,0.000555615,0.0004621439,0.0004914974,0.003310545],"category_scores_gemma":[0.0002689871,0.0002710277,0.0004188516,0.000165562,0.0006247777,0.0005157468,0.0002643724,0.001358148,0.0007349005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001870897,"about_ca_system_score_gemma":0.0002601659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004279526,"about_ca_topic_score_gemma":0.0007679855,"domain_scores_codex":[0.9995302,0.0000543786,0.00005444663,0.0001271978,0.0001244861,0.0001092904],"domain_scores_gemma":[0.9993472,0.00008395402,0.0001890769,0.0001123558,0.00004536847,0.000222125],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004003668,0.00006119332,0.0002744302,0.0000460681,0.00001252254,0.0000750796,0.00002506486,0.00003522993,0.9975311,0.0001194163,0.00005627633,0.001363277],"study_design_scores_gemma":[0.00006901914,0.0007334375,0.01216919,0.00001843371,0.0000819725,0.0006201995,0.00008617263,0.0007571387,0.9796503,0.0001616711,0.005633662,0.00001888363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867032,0.001443575,0.00810578,0.0002513145,0.0001200654,0.00004295558,0.0009355356,0.000453117,0.001944495],"genre_scores_gemma":[0.9870143,0.001036339,0.004270361,0.000143899,0.00003681164,0.0000899683,0.0009497536,0.0001774873,0.006281004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003310545,"threshold_uncertainty_score":0.01107484,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04255164183693572,"score_gpt":0.2535114193364064,"score_spread":0.2109597774994706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}