{"id":"W2790908907","doi":"10.2147/cia.s151453","title":"Gene-expression changes in knee-joint tissues with aging and menopause: implications for the joint as an organ","year":2018,"lang":"en","type":"article","venue":"Clinical Interventions in Aging","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Calgary","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Menopause; Medicine; Surgical Menopause; Gene expression; Ageing; Physiology; Knee Joint; Internal medicine; Gene; Endocrinology; Pathology; Biology; Surgery; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003097686,0.0001731699,0.0001978527,0.0002982299,0.0001500938,0.0002383267,0.0001172921,0.0002294656,0.0007340197],"category_scores_gemma":[0.0002901329,0.0001111298,0.0002815057,0.0001850965,0.0003972744,0.0002414931,0.0001230573,0.0002165222,0.0001529104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001729178,"about_ca_system_score_gemma":0.0001944518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003877442,"about_ca_topic_score_gemma":0.0006204495,"domain_scores_codex":[0.9998417,0.0000229114,0.00002092231,0.00004491441,0.00003963819,0.00002977363],"domain_scores_gemma":[0.999742,0.00005675004,0.00009892739,0.00001802851,0.00005213093,0.00003224362],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000126075,0.00002320628,0.005657863,0.00006014028,0.000007115108,0.0000871849,0.00007766715,0.00002211748,0.9923944,0.00005533861,0.00002365777,0.001465122],"study_design_scores_gemma":[0.00003070054,0.001939175,0.4810049,0.00004304451,0.0001056153,0.00147787,0.0007299713,0.0006337017,0.5105072,0.000225481,0.003279905,0.00002248054],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946989,0.002279198,0.001810932,0.00009006052,0.00002210407,0.00002411118,0.0003149795,0.00001976387,0.0007400751],"genre_scores_gemma":[0.9945639,0.001271553,0.002451133,0.0001026895,0.00001384866,0.00007685436,0.0003420969,0.000006314646,0.001171606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007340197,"threshold_uncertainty_score":0.002455592,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1294658319887167,"score_gpt":0.4352028131499338,"score_spread":0.3057369811612171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}