{"id":"W2790912769","doi":"10.1016/j.chemosphere.2018.02.003","title":"Covalent binding of the organophosphate insecticide profenofos to tyrosine on α- and β-tubulin proteins","year":2018,"lang":"en","type":"article","venue":"Chemosphere","topic":"Pesticide Exposure and Toxicity","field":"Agricultural and Biological Sciences","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carleton University; Environment and Climate Change Canada","funders":"Western Center for Agricultural Health and Safety; National Institute for Health and Care Research; National Institute on Minority Health and Health Disparities; National Institute for Occupational Safety and Health; National Institute of Food and Agriculture; National Institutes of Health","keywords":"Chemistry; Tubulin; Adduct; Peptide; Trypsin; Tyrosine; Covalent bond; Neurotoxicity; Biochemistry; Chromatography; Microtubule; Enzyme; Biology; Toxicity; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001732161,0.000226489,0.0001131034,0.0001079764,0.0003272531,0.0001789488,0.0002551361,0.000245922,0.001731277],"category_scores_gemma":[0.0002408837,0.0001298031,0.0001965513,0.0001321154,0.0002203883,0.0001709318,0.0002255423,0.0002893291,0.0002094535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004456944,"about_ca_system_score_gemma":0.000232495,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001918825,"about_ca_topic_score_gemma":0.003798885,"domain_scores_codex":[0.9998727,0.00002003291,0.000005219388,0.000028001,0.00002976073,0.00004418463],"domain_scores_gemma":[0.9998941,0.00002645224,0.00002945514,0.00001315694,0.00001779558,0.00001903311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000338025,0.00003679693,0.001352835,0.00004785522,0.00003784147,0.000119754,0.00006124063,0.0002602085,0.9950182,0.0003678845,0.0001006594,0.002258639],"study_design_scores_gemma":[0.00002657192,0.0003690906,0.01226535,0.000008783221,0.00002876962,0.0001714095,0.00007738377,0.0010797,0.9839469,0.000102743,0.001916845,0.000006347771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976442,0.0003580524,0.0006923404,0.00004733066,0.00001373342,0.000005218748,0.00004927979,0.00001154866,0.001178259],"genre_scores_gemma":[0.9975068,0.0003296064,0.0002838885,0.00002832944,0.000004676153,0.000003970038,0.0001820541,0.00000408605,0.001656728],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001918825,"threshold_uncertainty_score":0.005791724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01629774846293403,"score_gpt":0.2181818215238426,"score_spread":0.2018840730609086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}