{"id":"W2790919647","doi":"10.1002/jcph.1094","title":"Pharmacokinetics and Tolerability of Letermovir Coadministered With Azole Antifungals (Posaconazole or Voriconazole) in Healthy Subjects","year":2018,"lang":"en","type":"article","venue":"The Journal of Clinical Pharmacology","topic":"Cytomegalovirus and herpesvirus research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Pharma Medica Research (Canada)","funders":"Merck","keywords":"Posaconazole; Voriconazole; Tolerability; Medicine; Pharmacokinetics; Pharmacology; Azole; Internal medicine; Antifungal; Adverse effect; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004498963,0.0001806312,0.001182336,0.0001894807,0.00007434128,0.000009821013,0.0002959047,0.0001488464,0.0006767018],"category_scores_gemma":[0.0003815167,0.00009736647,0.000122794,0.0003403861,0.001334132,0.00009661761,0.0001270826,0.001123336,0.00001000985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004542844,"about_ca_system_score_gemma":0.0009329187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004724918,"about_ca_topic_score_gemma":0.00009467664,"domain_scores_codex":[0.9961658,0.0009056716,0.001881164,0.0002103901,0.0004353833,0.0004016636],"domain_scores_gemma":[0.9955617,0.002391245,0.0008397078,0.0002262365,0.0005906773,0.0003904436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.3707182,0.004395416,0.4285597,0.0006670747,0.0009261426,0.0007604284,0.001517178,0.00001572105,0.1416761,0.00002950523,0.01060566,0.04012896],"study_design_scores_gemma":[0.05465244,0.04842943,0.7603574,0.0003195556,0.00102834,0.001971387,0.0004116464,0.001329266,0.08707558,0.0001616075,0.04389185,0.000371507],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919144,0.0006524973,0.00003483428,0.005831593,0.0005932613,0.0004995844,0.00001246642,0.000006583095,0.0004547681],"genre_scores_gemma":[0.9919861,0.002246074,0.0002371186,0.004309487,0.001098298,0.000003185157,7.811695e-7,0.00002056216,0.0000983809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3317977,"threshold_uncertainty_score":0.740941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1322770009064881,"score_gpt":0.4870529437690764,"score_spread":0.3547759428625883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}