{"id":"W2790957764","doi":"10.1038/s41418-018-0074-y","title":"Nrf3 promotes UV-induced keratinocyte apoptosis through suppression of cell adhesion","year":2018,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"University of California, San Francisco; Eidgenössische Technische Hochschule Zürich; Wilhelm Sander-Stiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Cell biology; Keratinocyte; Focal adhesion; Apoptosis; Motility; Cell adhesion; Integrin; Transcription factor; Chemistry; Extracellular matrix; Epidermis (zoology); Programmed cell death; Cell; Biology; Signal transduction; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008925362,0.000201554,0.0001659701,0.0001763305,0.0001498826,0.0001439349,0.00009138152,0.0001716239,0.001730525],"category_scores_gemma":[0.00006792158,0.0000755912,0.0002814769,0.00009357148,0.0001248123,0.0001532708,0.0001486764,0.0003142935,0.0002954978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001400867,"about_ca_system_score_gemma":0.0001157484,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004261477,"about_ca_topic_score_gemma":0.0007949728,"domain_scores_codex":[0.9999291,0.00001374245,0.000007116466,0.00001237855,0.00001794399,0.00001961566],"domain_scores_gemma":[0.999953,0.000004975358,0.00001295463,0.000006390497,0.00000998321,0.00001256259],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001409702,0.00002511438,0.0001655556,0.00004800833,0.000006011333,0.00004827126,0.00001085123,0.00001518123,0.9983199,0.00004543808,0.00004860969,0.001125929],"study_design_scores_gemma":[0.00002331109,0.0002431651,0.008999339,0.000009404474,0.00002277369,0.0003299909,0.00004968324,0.0003682213,0.9866965,0.00008445571,0.003168612,0.000004444122],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929812,0.002941289,0.001736317,0.0001401646,0.00003075771,0.00001938542,0.0003049533,0.00008957533,0.001756405],"genre_scores_gemma":[0.996224,0.000955194,0.0006607834,0.00004502842,0.000005901843,0.00001598382,0.0002191211,0.000008125883,0.001865874],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001730525,"threshold_uncertainty_score":0.00578922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654617871672991,"score_gpt":0.2446579170042334,"score_spread":0.2281117382875035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}