{"id":"W2790957764","doi":"10.1038/s41418-018-0074-y","title":"Nrf3 promotes UV-induced keratinocyte apoptosis through suppression of cell adhesion","year":2018,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"University of California, San Francisco; Eidgenössische Technische Hochschule Zürich; Wilhelm Sander-Stiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Cell biology; Keratinocyte; Focal adhesion; Apoptosis; Motility; Cell adhesion; Integrin; Transcription factor; Chemistry; Extracellular matrix; Epidermis (zoology); Programmed cell death; Cell; Biology; Signal transduction; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004153233,0.0001571872,0.000154304,0.00002539672,0.0000994672,0.00002262498,0.00009464654,0.0001562883,0.00003127289],"category_scores_gemma":[0.00002400018,0.0001368108,0.00005959311,0.00003546188,0.00005157694,0.000009333536,0.00009407785,0.00005322345,0.00000700706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000666533,"about_ca_system_score_gemma":0.00001715758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001497733,"about_ca_topic_score_gemma":0.000003419437,"domain_scores_codex":[0.9991489,0.00004752046,0.0002090429,0.0003271191,0.00009486399,0.000172567],"domain_scores_gemma":[0.9994323,0.00001098149,0.0001514414,0.0002268156,0.0001165106,0.00006199625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008322571,0.0001100455,0.00666572,0.00007287126,0.000009510346,5.977254e-8,0.0001946213,2.470775e-7,0.9922152,0.00001740705,0.0002285156,0.0004025452],"study_design_scores_gemma":[0.0006557069,0.0003830064,0.0154782,0.00002115514,0.00003064311,3.780331e-7,0.00005431371,0.00009139222,0.982645,0.0002934174,0.0001950722,0.0001517559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954205,0.0002517258,0.001647535,0.0000151019,0.0001561638,0.0001965114,0.00001988983,0.000008584977,0.002284007],"genre_scores_gemma":[0.9976798,0.0002024844,0.001261927,0.00004111398,0.0002282246,0.0000108587,0.0003071919,0.00001545266,0.000252963],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009570271,"threshold_uncertainty_score":0.5578985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654617871672991,"score_gpt":0.2446579170042334,"score_spread":0.2281117382875035,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}