{"id":"W2791016890","doi":"10.3390/ijms19020369","title":"Skeleton-Controlled pDNA Delivery of Renewable Steroid-Based Cationic Lipids, the Endocytosis Pathway Analysis and Intracellular Localization","year":2018,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Natural Science Foundation of China; Agência Regional para o Desenvolvimento da Investigação, Tecnologia e Inovação; Youth Innovation Promotion Association; National Science Foundation","keywords":"Endocytosis; Transfection; Gene delivery; Cell biology; Steroid; Intracellular; Chemistry; Cytotoxicity; Cationic liposome; Endosome; HeLa; Biochemistry; Biology; Cell; Hormone; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001406687,0.0003085998,0.0001508384,0.000166964,0.0001131011,0.0001869256,0.0001481249,0.0002748747,0.0003386157],"category_scores_gemma":[0.0001679511,0.00008641704,0.0001680018,0.0001278594,0.0002319769,0.0003280547,0.0002818752,0.000268327,0.0001963058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002797694,"about_ca_system_score_gemma":0.0002992304,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004749639,"about_ca_topic_score_gemma":0.0006883531,"domain_scores_codex":[0.9999259,0.000009749006,0.000007697535,0.00002079818,0.00002156076,0.00001429573],"domain_scores_gemma":[0.9999297,0.00001006982,0.00002295584,0.000007319293,0.00001737804,0.00001250938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001499765,0.000003478604,0.00007049368,0.00003925825,0.00000181047,0.00003152471,0.00001216496,0.00007470767,0.9980085,0.0001509128,0.0000143397,0.001577834],"study_design_scores_gemma":[0.000003361322,0.00002651381,0.0001775734,0.000001468087,0.000003488179,0.00005054758,0.000007143401,0.0005720481,0.9980877,0.00002488636,0.001041855,0.000003404647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9680386,0.003385442,0.02600372,0.0001511383,0.00003800416,0.00008265136,0.0001766899,0.0001360273,0.00198789],"genre_scores_gemma":[0.982176,0.001842325,0.0138898,0.00005495532,0.00001034968,0.00005348264,0.0001195581,0.0000212711,0.001832251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004749639,"threshold_uncertainty_score":0.002029896,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008463553381724288,"score_gpt":0.2484538707124387,"score_spread":0.2399903173307145,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}