{"id":"W2791052413","doi":"10.1016/s0735-1097(18)31896-5","title":"APABETALONE (RVX-208) MODULATES EPIGENETIC PROCESSES IN MONOCYTES AND ENDOTHELIAL CELLS AFFECTED BY DIABETES MELLITUS AND DIET THAT ENHANCE RISK OF CARDIOVASCULAR DISEASE (CVD)","year":2018,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Resverlogix (Canada)","funders":"","keywords":"Bromodomain; Medicine; Mace; Epigenetics; Diabetes mellitus; Disease; Internal medicine; Endocrinology; Bioinformatics; Biochemistry; Myocardial infarction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008612145,0.0001963481,0.0002142856,0.0001270993,0.000117755,0.0002139392,0.000115222,0.0001839238,0.001369765],"category_scores_gemma":[0.0001005911,0.0001059036,0.000173311,0.0001230008,0.0001522585,0.0001138569,0.0001435963,0.0003887307,0.0002148773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001162024,"about_ca_system_score_gemma":0.0002008421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006285051,"about_ca_topic_score_gemma":0.001037934,"domain_scores_codex":[0.9999371,0.00001608943,0.000005350028,0.000009813031,0.000008438685,0.00002322293],"domain_scores_gemma":[0.9999548,0.000004515794,0.00001257793,0.000004458291,0.000006089132,0.00001752915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005806063,0.0001943138,0.002095514,0.00008162242,0.00004063863,0.0001440754,0.00002803278,0.00007279274,0.983813,0.0001501203,0.0001742828,0.007399403],"study_design_scores_gemma":[0.0007329893,0.005149382,0.09137569,0.00002689066,0.0002607093,0.0006869156,0.0002494655,0.001463933,0.8945287,0.0004096691,0.005088609,0.0000270097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972069,0.001439439,0.0004582852,0.0001062112,0.00004704213,0.000009405159,0.0001908747,0.00002830565,0.0005135288],"genre_scores_gemma":[0.9972678,0.000858587,0.0003503254,0.00005213832,0.00001268343,0.00001997419,0.0001819883,0.000004764149,0.001251617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001369765,"threshold_uncertainty_score":0.004582345,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004715097537930775,"score_gpt":0.2087585934866829,"score_spread":0.2040434959487522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}