{"id":"W2791070352","doi":"10.1101/gad.305854.117","title":"Pivotal role of NAMPT in the switch of melanoma cells toward an invasive and drug-resistant phenotype","year":2018,"lang":"en","type":"article","venue":"Genes & Development","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National Du Cancer; Institut National de la Santé et de la Recherche Médicale; Université de Lille; Université de Moncton","keywords":"Nicotinamide phosphoribosyltransferase; Melanoma; Biology; NAD+ kinase; Cancer research; Phenotype; Nicotinamide adenine dinucleotide; Transcriptome; Epigenetics; Sirtuin 1; Downregulation and upregulation; Gene expression; Enzyme; Gene; Genetics; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007980075,0.0002641457,0.0002172035,0.0001295431,0.0001426318,0.000229019,0.00009994565,0.0002201945,0.001083378],"category_scores_gemma":[0.00005572235,0.00007317197,0.0002268781,0.00007223174,0.0001816043,0.0001623178,0.0001696947,0.000241823,0.0002111402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001640296,"about_ca_system_score_gemma":0.0001298985,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002748317,"about_ca_topic_score_gemma":0.0006371642,"domain_scores_codex":[0.9999424,0.00001176625,0.000003574594,0.00001884697,0.00001287511,0.00001055786],"domain_scores_gemma":[0.9999654,0.000003225247,0.000008627851,0.000004400485,0.000006076718,0.00001233243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001048783,0.000007932801,0.0003445159,0.00003590679,0.000005136908,0.00007983671,0.00001608987,0.00002686244,0.9970811,0.0001731006,0.00003249389,0.002092209],"study_design_scores_gemma":[0.00001916582,0.000391199,0.02296897,0.00001522047,0.00003092509,0.0008566504,0.0001496151,0.0008040636,0.9661019,0.0007542396,0.00789588,0.00001216767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722106,0.009602875,0.008688014,0.0003967392,0.0001024217,0.00004729886,0.0008618064,0.0001898066,0.007900431],"genre_scores_gemma":[0.9931028,0.00134023,0.002495849,0.00007388731,0.000009422267,0.00001395706,0.0003002141,0.00001506626,0.002648598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001083378,"threshold_uncertainty_score":0.00362426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301699184610327,"score_gpt":0.2452716368944409,"score_spread":0.2322546450483376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}