{"id":"W2791085293","doi":"10.1074/jbc.ra118.002053","title":"An auto-inhibitory helix in CTP:phosphocholine cytidylyltransferase hijacks the catalytic residue and constrains a pliable, domain-bridging helix pair","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University; University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates - Technology Futures","keywords":"Helix (gastropod); Dimer; Phosphocholine; Stereochemistry; Chemistry; Helix bundle; Membrane; Biophysics; Protein subunit; Protein structure; Phosphatidylcholine; Crystallography; Biochemistry; Phospholipid; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000101651,0.0002760431,0.0001950059,0.00005649713,0.0002312252,0.0002709649,0.0003328993,0.0003347375,0.00107022],"category_scores_gemma":[0.0001556197,0.0001638491,0.0001954619,0.00007694407,0.000271902,0.0003101779,0.0002549303,0.0005273801,0.0003891176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003307084,"about_ca_system_score_gemma":0.0002843447,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001152026,"about_ca_topic_score_gemma":0.0011543,"domain_scores_codex":[0.9999522,0.000007017939,0.000003140899,0.00001268395,0.00001216956,0.00001283738],"domain_scores_gemma":[0.9999567,0.000006010362,0.00001022999,0.000003180071,0.000004348404,0.00001949992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004505172,0.000101427,0.001358167,0.0001068219,0.00003106873,0.0004330349,0.00006752498,0.005415835,0.9859802,0.001945994,0.0002780343,0.003831424],"study_design_scores_gemma":[0.0002946866,0.0010245,0.00957284,0.0000498194,0.0001020683,0.0008617718,0.0002245317,0.1315307,0.8435002,0.001430833,0.01134795,0.00006005271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943056,0.0003238115,0.004250704,0.0000720013,0.00003286924,0.00001215238,0.00003613472,0.00008172049,0.0008850251],"genre_scores_gemma":[0.9973829,0.0001169915,0.001501231,0.00003826775,0.000003952214,0.000008697945,0.00007730261,0.00001273092,0.0008579748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001152026,"threshold_uncertainty_score":0.003580272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01470491044880105,"score_gpt":0.2768228144464989,"score_spread":0.2621179039976979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}