{"id":"W2791106424","doi":"10.1016/j.molcel.2018.02.002","title":"The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair","year":2018,"lang":"en","type":"article","venue":"Molecular Cell","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University","funders":"National Institute of General Medical Sciences; National Cancer Institute; European Research Council; Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Universidad de Sevilla; Medical Research Council; Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; National Science Foundation; A-T Children's Project; American Cancer Society; Israel Cancer Research Fund; Israel Science Foundation; National Natural Science Foundation of China; Ministerio de Economía y Competitividad","keywords":"Ubiquitin ligase; Biology; Ubiquitin; DNA repair; DNA damage; Homologous recombination; DNA ligase; Cell biology; DNA; DNA Ligases; Genetics; Molecular biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003342015,0.0004463079,0.0004282164,0.0007494318,0.0005336262,0.0009930846,0.0004588672,0.0005696334,0.002870761],"category_scores_gemma":[0.0003244959,0.0003908154,0.0004813746,0.0004760785,0.0004647399,0.0006078647,0.0007486438,0.0006065203,0.001192017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007624105,"about_ca_system_score_gemma":0.0002858829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005979388,"about_ca_topic_score_gemma":0.0007579044,"domain_scores_codex":[0.9997147,0.00003653239,0.00001708419,0.00008886583,0.00007155793,0.00007141327],"domain_scores_gemma":[0.9997761,0.00001755246,0.00006001714,0.00004817258,0.00004277862,0.00005542357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001961394,0.00002973243,0.001066426,0.00003691632,0.00002334544,0.00005427119,0.000009826601,0.0002218019,0.9929744,0.000391465,0.0001383136,0.004857285],"study_design_scores_gemma":[0.0000126712,0.00005766015,0.005312799,0.000002481907,0.00001304991,0.0001734378,0.00002399467,0.001244738,0.9896298,0.0002445016,0.003276897,0.00000801047],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684855,0.00482532,0.02093916,0.0004349886,0.0001582923,0.00004591891,0.0005461266,0.0006800899,0.003884627],"genre_scores_gemma":[0.9892023,0.000792436,0.005397794,0.00006274836,0.00001580663,0.00001332503,0.0003539423,0.00007822905,0.004083305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002870761,"threshold_uncertainty_score":0.009603679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01666733350925457,"score_gpt":0.2667753621186635,"score_spread":0.2501080286094089,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}