{"id":"W2791126850","doi":"10.1128/jb.00050-18","title":"A Single Amino Acid Change in the Response Regulator PhoP, Acquired during Yersinia pestis Evolution, Affects PhoP Target Gene Transcription and Polymyxin B Susceptibility","year":2018,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Yersinia bacterium, plague, ectoparasites research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Canadian Institute for Advanced Research; Toronto Metropolitan University","funders":"National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council","keywords":"Biology; Yersinia pestis; Virulence; Mutant; Genetics; Gene; Response regulator; Microbiology; Yersinia pseudotuberculosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001112405,0.0003021547,0.0001695214,0.0001346618,0.00008693113,0.0001979504,0.00017712,0.0003253558,0.0009221046],"category_scores_gemma":[0.0001803906,0.0001035298,0.0002142893,0.0001497784,0.0002233327,0.0001276451,0.0001566341,0.0003544517,0.0001809475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001792868,"about_ca_system_score_gemma":0.00007179081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005879278,"about_ca_topic_score_gemma":0.0004441318,"domain_scores_codex":[0.9998964,0.00002235014,0.00001390868,0.00002640937,0.00001794422,0.00002290208],"domain_scores_gemma":[0.9998574,0.00003333793,0.00004684275,0.00001099306,0.00001105583,0.00004025958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002769866,0.00003007348,0.001021616,0.00001205173,0.000008080184,0.0001140384,0.00001160639,0.0000376653,0.9980661,0.00001503692,0.000009285965,0.0003975084],"study_design_scores_gemma":[0.00005792111,0.001420344,0.1163963,0.00001069297,0.00007516645,0.00140903,0.0001382544,0.001666956,0.8776385,0.00004117474,0.00112497,0.00002075496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994037,0.00009909501,0.0001859299,0.00001268772,0.000007030847,0.00000433362,0.0001348152,0.000006331484,0.0001460734],"genre_scores_gemma":[0.9993439,0.00005387884,0.0001528804,0.00001649796,0.000002765618,0.000004087509,0.0001900656,0.000004472887,0.0002313525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009221046,"threshold_uncertainty_score":0.003084779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01792021972514453,"score_gpt":0.2715055761020325,"score_spread":0.2535853563768879,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}