{"id":"W2791154088","doi":"10.1038/s41375-018-0023-2","title":"Ibrutinib versus temsirolimus: 3-year follow-up of patients with previously treated mantle cell lymphoma from the phase 3, international, randomized, open-label RAY study","year":2018,"lang":"en","type":"article","venue":"Leukemia","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":99,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"Celgene; Pfizer","keywords":"Ibrutinib; Mantle cell lymphoma; Temsirolimus; Medicine; Lymphoma; Open label; Internal medicine; Oncology; Phases of clinical research; Randomized controlled trial; Clinical trial; Leukemia; Chemistry; Discovery and development of mTOR inhibitors; Chronic lymphocytic leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002448616,0.0002712084,0.0007076931,0.00005447349,0.0001166951,0.0000691795,0.0004183733,0.00007297858,0.0003354815],"category_scores_gemma":[0.0001294322,0.0001460015,0.000102082,0.0001748316,0.0001866611,0.0001212825,0.0001694433,0.00005533872,0.0001309455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005114788,"about_ca_system_score_gemma":0.000278898,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002689034,"about_ca_topic_score_gemma":0.0001856798,"domain_scores_codex":[0.9982349,0.000159537,0.0004554414,0.0004201489,0.0004835854,0.0002464076],"domain_scores_gemma":[0.9981592,0.0004988899,0.0002992302,0.0006424963,0.0002828831,0.0001172512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.6324303,0.02056669,0.3156214,0.00001978449,0.00348286,0.00009077748,0.004158036,0.00000108761,0.00008436311,0.00004670649,0.0126911,0.01080693],"study_design_scores_gemma":[0.9463271,0.004616085,0.0417919,0.0001261292,0.001385924,9.966041e-7,0.0004746956,0.0001173834,0.002141281,0.000009593947,0.002842565,0.0001663098],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899439,0.0001283833,0.000006154189,0.0001066342,0.0005117838,0.00316993,0.0001619995,0.0000367095,0.005934485],"genre_scores_gemma":[0.9977636,0.00005912476,0.0002511012,0.0002090315,0.0001794008,0.0002677543,0.0003891637,0.00003825738,0.0008425771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3138969,"threshold_uncertainty_score":0.5953769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02692729041299204,"score_gpt":0.3007514503850554,"score_spread":0.2738241599720633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}