{"id":"W2791162091","doi":"10.1038/s41388-018-0152-0","title":"Beyond molecular tumor heterogeneity: protein synthesis takes control","year":2018,"lang":"en","type":"review","venue":"Oncogene","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Agència de Gestió d'Ajuts Universitaris i de Recerca; Centro de Investigación Biomédica en Red de Cáncer; Generalitat de Catalunya","keywords":"Biology; EIF4E; Cancer research; Hypoxia (environmental); Phosphorylation; Immune system; Gene; Computational biology; Immunology; Cell biology; Genetics; Translation (biology); Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004639461,0.0008443493,0.001651367,0.0001250737,0.0001172667,0.00007551558,0.0009164681,0.0007067258,0.0001354195],"category_scores_gemma":[0.0003064557,0.0007582714,0.001049261,0.0001994303,0.0002268217,0.000003758402,0.0001593031,0.0002547873,0.0002580966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001296076,"about_ca_system_score_gemma":0.0007276044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000107947,"about_ca_topic_score_gemma":0.00001428191,"domain_scores_codex":[0.996511,0.000425816,0.0007514765,0.001253575,0.000388733,0.0006694346],"domain_scores_gemma":[0.9975065,0.00004821093,0.0005992093,0.001413459,0.0001893751,0.000243275],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000117788,0.0002468661,0.000005700403,0.008731079,0.00305669,0.0002860037,0.00000920381,0.000006489828,0.3405549,0.00005054801,0.006663477,0.6402713],"study_design_scores_gemma":[0.0002561417,0.000264987,9.177441e-8,0.002040912,0.0008283331,0.0001051581,0.000001645615,0.000001710252,0.1881486,0.00001959366,0.8076368,0.0006960355],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001057042,0.9940695,0.0007912047,0.00002551572,0.0004305643,0.001407044,0.000589359,0.00004734661,0.001582486],"genre_scores_gemma":[0.001955205,0.9896162,0.001863437,0.0004761776,0.002471001,0.002123947,0.0003813319,0.0003740621,0.0007386118],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8009733,"threshold_uncertainty_score":0.9994868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02199741316663272,"score_gpt":0.3067498476777394,"score_spread":0.2847524345111067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}