{"id":"W2791214532","doi":"10.1371/journal.pone.0191240","title":"The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer’s disease","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Servier; National Heart, Lung, and Blood Institute; Vetenskapsrådet; Eisai; Northern California Institute for Research and Education; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Svenska Forskningsrådet Formas; Royal Swedish Academy of Sciences; Foundation for the National Institutes of Health","keywords":"Cerebrospinal fluid; Alzheimer's disease; Disease; Medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002687239,0.0004520982,0.0003656496,0.001035672,0.0003313813,0.000708786,0.0004429652,0.0004319421,0.001048511],"category_scores_gemma":[0.008689953,0.0003015409,0.000435859,0.0006965891,0.0004435987,0.0009419808,0.0007595754,0.0006528672,0.0005074049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004845172,"about_ca_system_score_gemma":0.0005721367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005956815,"about_ca_topic_score_gemma":0.004785072,"domain_scores_codex":[0.9993091,0.0002644542,0.0000708437,0.0001561384,0.0001365101,0.00006294879],"domain_scores_gemma":[0.9957753,0.002077045,0.001055791,0.0003461112,0.0004991284,0.0002466145],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007306878,0.00007452048,0.989521,0.00003123203,0.0001250718,0.0001398534,0.0002386061,0.001483663,0.001559596,0.0001205424,0.0001034436,0.005871748],"study_design_scores_gemma":[0.00001183344,0.0002766596,0.9871889,0.0000193523,0.00005523138,0.0004583602,0.00019559,0.009240489,0.0007222915,0.00139659,0.0004208403,0.00001384192],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981712,0.000454434,0.0007543171,0.00005773071,0.000006633528,0.000004403044,0.0001405535,0.000007983301,0.000402805],"genre_scores_gemma":[0.9992181,0.000140904,0.0003058505,0.0000114577,0.000006381138,0.000004339771,0.0001597989,0.000003057449,0.0001500888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005956815,"threshold_uncertainty_score":0.01421165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2038494472161392,"score_gpt":0.3870134461918738,"score_spread":0.1831639989757346,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}