{"id":"W2791219533","doi":"10.1080/15592294.2018.1435243","title":"Breast cancer family history and allele-specific DNA methylation in the legacy girls study","year":2018,"lang":"en","type":"article","venue":"Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Cancer Institute; National Institutes of Health; Children's Hospital of Philadelphia; National Institute of Environmental Health Sciences; Avon Foundation for Women","keywords":"Biology; DNA methylation; Epigenetics; Methylation; Genetics; Differentially methylated regions; Breast cancer; Allele; Cancer; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000552567,0.0001742847,0.0001403801,0.00006791436,0.00009713498,0.0000427487,0.0002134887,0.0001226313,0.00003766003],"category_scores_gemma":[0.00001931602,0.0001444183,0.0000391067,0.0001171139,0.0001512251,0.000006787001,0.00007850354,0.0001044463,0.000007938324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004878336,"about_ca_system_score_gemma":0.00007163055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001243484,"about_ca_topic_score_gemma":0.0006073633,"domain_scores_codex":[0.9986429,0.0002288497,0.0002842167,0.0003980072,0.0002131237,0.0002328872],"domain_scores_gemma":[0.9992573,0.00002605344,0.00009662841,0.0004363911,0.0001285409,0.00005510278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001474889,0.0004550744,0.09786125,0.00001465075,0.00006952958,0.000006261898,0.003800421,0.0001584054,0.8017089,0.0001166739,0.003184974,0.09247641],"study_design_scores_gemma":[0.0008336635,0.0005948045,0.8147501,0.00000691819,0.00002986085,0.00000375517,0.0008004339,0.00009911243,0.02641611,0.0002087371,0.1559554,0.0003010151],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9804159,0.01672135,0.0008186226,0.0001982006,0.0003055655,0.0004118427,0.00001138174,0.000007445979,0.001109624],"genre_scores_gemma":[0.9953405,0.003223957,0.0003127162,0.0001897893,0.0006629946,0.00004627861,0.00002887692,0.00002588517,0.0001690135],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7752928,"threshold_uncertainty_score":0.5889207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02910921627713879,"score_gpt":0.2803411115390212,"score_spread":0.2512318952618824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}