{"id":"W2791219533","doi":"10.1080/15592294.2018.1435243","title":"Breast cancer family history and allele-specific DNA methylation in the legacy girls study","year":2018,"lang":"en","type":"article","venue":"Epigenetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Cancer Institute; National Institutes of Health; Children's Hospital of Philadelphia; National Institute of Environmental Health Sciences; Avon Foundation for Women","keywords":"Biology; DNA methylation; Epigenetics; Methylation; Genetics; Differentially methylated regions; Breast cancer; Allele; Cancer; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006606798,0.0002263631,0.0004612419,0.0003675643,0.0005124493,0.0005559206,0.0004285919,0.0003081051,0.001890051],"category_scores_gemma":[0.001480299,0.0002879885,0.0004086426,0.0007125723,0.0002256277,0.0002108169,0.000784442,0.0006014598,0.0002893752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002196646,"about_ca_system_score_gemma":0.0003055793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01425267,"about_ca_topic_score_gemma":0.01579926,"domain_scores_codex":[0.9995701,0.00009942913,0.00003847574,0.000162228,0.00008042723,0.00004937105],"domain_scores_gemma":[0.9991872,0.00009700045,0.0002835051,0.0001218503,0.00007769796,0.000232878],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001623334,0.00002020887,0.9972518,0.000009302595,0.00009621953,0.0000942288,0.0001978254,0.0000175347,0.0009320164,0.00002801024,0.0001538228,0.001036677],"study_design_scores_gemma":[0.00001421235,0.00006513464,0.9988328,0.00000490273,0.00004286852,0.0002392307,0.0001902723,0.00003581071,0.000173701,0.00001557627,0.0003832899,0.000002262839],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972633,0.0001430386,0.0001312107,0.00003776732,0.000004713369,0.00001273661,0.002080351,0.000004039377,0.0003227477],"genre_scores_gemma":[0.9974836,0.0001329526,0.0002288527,0.00002710798,0.000005736038,0.00001890087,0.001562641,0.00000977578,0.0005306056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01425267,"threshold_uncertainty_score":0.02833939,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02910921627713879,"score_gpt":0.2803411115390212,"score_spread":0.2512318952618824,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}