{"id":"W2791296995","doi":"10.3389/fncel.2018.00022","title":"SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury","year":2018,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal General Hospital","funders":"FP7 People: Marie-Curie Actions; Canadian Institutes of Health Research; Canada Excellence Research Chairs, Government of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canada Research Chairs; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"AMPA receptor; Astrocyte; Glutamate receptor; Microglia; Downregulation and upregulation; Synaptic plasticity; Receptor; Neuroscience; Matricellular protein; Context (archaeology); Chemistry; Biology; Cell biology; Central nervous system; Inflammation; Immunology; Biochemistry; Extracellular matrix","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001268382,0.000342641,0.0005845281,0.0002300066,0.0002154006,0.0002806909,0.0001464925,0.0003395655,0.0008987281],"category_scores_gemma":[0.00009871488,0.0001140301,0.0003649296,0.0002419692,0.0003011657,0.0002350836,0.0003053778,0.0006751199,0.0002360653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002770929,"about_ca_system_score_gemma":0.0003433218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008011211,"about_ca_topic_score_gemma":0.001390137,"domain_scores_codex":[0.9998168,0.00001530323,0.00002070058,0.00003526132,0.00004973749,0.00006218822],"domain_scores_gemma":[0.9998834,0.000007046562,0.00003469379,0.00001066939,0.00002195007,0.00004219422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003462292,0.00003064825,0.0002791552,0.00009448718,0.00001201843,0.00009688307,0.000027338,0.00002412116,0.9973016,0.00003149791,0.00003684263,0.001719252],"study_design_scores_gemma":[0.00003009991,0.001064898,0.03882964,0.00002920791,0.00007014021,0.000550392,0.0001315458,0.0003894689,0.9557874,0.00006881474,0.003038565,0.000009794758],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916176,0.006173544,0.0009369617,0.0001393693,0.000036363,0.00002448457,0.0002553005,0.000045545,0.0007707354],"genre_scores_gemma":[0.992493,0.003993233,0.001021926,0.000106316,0.00002908658,0.00005342692,0.0004713841,0.00001067194,0.001820921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008987281,"threshold_uncertainty_score":0.003006518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239536658576536,"score_gpt":0.2849168931183475,"score_spread":0.2625215265325822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}