{"id":"W2791296995","doi":"10.3389/fncel.2018.00022","title":"SPARC and GluA1-Containing AMPA Receptors Promote Neuronal Health Following CNS Injury","year":2018,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Montreal General Hospital","funders":"FP7 People: Marie-Curie Actions; Canadian Institutes of Health Research; Canada Excellence Research Chairs, Government of Canada; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Canada Research Chairs; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada","keywords":"AMPA receptor; Astrocyte; Glutamate receptor; Microglia; Downregulation and upregulation; Synaptic plasticity; Receptor; Neuroscience; Matricellular protein; Context (archaeology); Chemistry; Biology; Cell biology; Central nervous system; Inflammation; Immunology; Biochemistry; Extracellular matrix","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005613583,0.0001936376,0.0003949381,0.0001967504,0.0003538734,0.00004816307,0.0001500837,0.00005275016,0.000005993958],"category_scores_gemma":[0.0002217737,0.0001793436,0.00007086758,0.0005265492,0.0005402238,0.0002039273,0.0001940744,0.0002942705,0.000006245201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008087304,"about_ca_system_score_gemma":0.0001267261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008190222,"about_ca_topic_score_gemma":0.00001026336,"domain_scores_codex":[0.9980028,0.00008572326,0.0003237983,0.0006301795,0.000414794,0.0005426942],"domain_scores_gemma":[0.9993762,0.00001473907,0.0001016691,0.0002571708,0.00002682364,0.0002234248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000589155,0.0003163183,0.7080791,0.0001887212,0.00002360232,0.0003997789,0.003757298,0.000002102473,0.1909315,0.00009926964,0.01431157,0.08130157],"study_design_scores_gemma":[0.009420763,0.02352268,0.4611729,0.001979639,0.000185476,0.0003400024,0.005392787,0.0162843,0.2201919,0.003107475,0.2558095,0.002592619],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870067,0.00119161,0.005603313,0.001307636,0.003586921,0.0005777138,0.000002680202,0.00006771796,0.0006557537],"genre_scores_gemma":[0.9908398,0.0001538507,0.005777842,0.002466732,0.0001520384,0.00001376489,0.000001864568,0.00002323562,0.0005708297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2469062,"threshold_uncertainty_score":0.7313419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02239536658576536,"score_gpt":0.2849168931183475,"score_spread":0.2625215265325822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}