{"id":"W2791343984","doi":"10.1093/jcag/gwy008.147","title":"A146 ASSESSMENT OF THE USE OF THERAPEUTIC DRUG MONITORING OF INFLIXIMAB DURING MAINTENANCE IN CHILDREN WITH INFLAMMATORY BOWEL DISEASE","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Infliximab; Maintenance therapy; Therapeutic drug monitoring; Inflammatory bowel disease; Internal medicine; Retrospective cohort study; Drug; Trough level; Cohort; Cohort study; Disease; Pharmacokinetics; Pharmacology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005741724,0.00007919397,0.0003112195,0.0001082758,0.0000528766,0.000004178931,0.0001831064,0.00003634072,0.00001006648],"category_scores_gemma":[0.0003019461,0.00004661072,0.0001182915,0.000105622,0.0001668102,0.0001040256,0.00004276691,0.0002869808,7.243241e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005186149,"about_ca_system_score_gemma":0.0003361549,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001546921,"about_ca_topic_score_gemma":0.021246,"domain_scores_codex":[0.9986047,0.0002665374,0.0005235103,0.00006269671,0.0003360202,0.0002065685],"domain_scores_gemma":[0.9975302,0.0000980681,0.001701169,0.0001497023,0.0004082505,0.0001126422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000698333,0.00006714163,0.9973993,0.00003857367,0.0004577624,0.000001963093,0.0001966933,0.0002279403,0.0007839587,0.00001364106,0.0000751751,0.00003947901],"study_design_scores_gemma":[0.002013196,0.0002664865,0.9963566,0.0002596069,0.0002164391,0.00001425509,0.00006754724,0.00006538798,0.0005764365,0.00001437616,0.0001269471,0.00002271173],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930176,0.00004172885,0.00000415694,0.006560598,0.0001689599,0.0001654255,0.00001980091,7.156733e-7,0.0000210664],"genre_scores_gemma":[0.9993994,0.00007601079,0.0001093244,0.0002843378,0.00007921669,0.000001432898,2.237511e-7,0.000006946282,0.00004308667],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01969908,"threshold_uncertainty_score":0.9966137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0196490922741671,"score_gpt":0.2888568812152363,"score_spread":0.2692077889410692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}