{"id":"W2791343984","doi":"10.1093/jcag/gwy008.147","title":"A146 ASSESSMENT OF THE USE OF THERAPEUTIC DRUG MONITORING OF INFLIXIMAB DURING MAINTENANCE IN CHILDREN WITH INFLAMMATORY BOWEL DISEASE","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont; Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Medicine; Infliximab; Maintenance therapy; Therapeutic drug monitoring; Inflammatory bowel disease; Internal medicine; Retrospective cohort study; Drug; Trough level; Cohort; Cohort study; Disease; Pharmacokinetics; Pharmacology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001016456,0.0002514945,0.000443318,0.001119944,0.0003528422,0.0007195659,0.0003389751,0.0004893114,0.0008533612],"category_scores_gemma":[0.00537413,0.0002175561,0.0004436166,0.001456561,0.0002649669,0.0005312288,0.000380126,0.0006066927,0.0001864187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006983828,"about_ca_system_score_gemma":0.0006958552,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003519287,"about_ca_topic_score_gemma":0.002719189,"domain_scores_codex":[0.9984628,0.0003131851,0.0002817691,0.0002387356,0.000506402,0.0001971483],"domain_scores_gemma":[0.9943234,0.0007727703,0.003711392,0.0001882584,0.0006258849,0.0003783489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000083014,0.00001488156,0.9978141,0.00002512192,0.00001502713,0.0001025166,0.000102545,0.00002186228,0.0001015602,0.000008883949,0.00005783617,0.001652717],"study_design_scores_gemma":[0.000003297333,0.0002223155,0.9981212,0.000018495,0.00002211517,0.0008873791,0.0001648396,0.00005463251,0.0001044521,0.000005020751,0.0003921628,0.000004180769],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974387,0.001202843,0.0001248391,0.00005090532,0.000007893213,0.00001788674,0.0005509421,0.000004380942,0.0006017693],"genre_scores_gemma":[0.9988788,0.0004149751,0.0001931036,0.00002268797,0.0000112571,0.0000211547,0.0003735517,0.00000306777,0.00008137742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003519287,"threshold_uncertainty_score":0.006997645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0196490922741671,"score_gpt":0.2888568812152363,"score_spread":0.2692077889410692,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}