{"id":"W2791345234","doi":"10.1093/jcag/gwy009.046","title":"A46 THE IMPACT OF CYP2C19 POLYMORPHISM ON PROTON PUMP INHIBITORS DOSING: A RETROSPECTIVE ANALYSIS","year":2018,"lang":"en","type":"article","venue":"Journal of the Canadian Association of Gastroenterology","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"","keywords":"CYP2C19; Lansoprazole; Medicine; Dosing; Pantoprazole; Pharmacology; Esomeprazole; Pharmacogenomics; Internal medicine; Pharmacogenetics; Proton-pump inhibitor; Pharmacokinetics; Population; Maintenance dose; Omeprazole; Gastroenterology; Genotype; Cytochrome P450; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001048199,0.0002544908,0.0005564147,0.001099051,0.0004824205,0.000605049,0.0003634528,0.0003753762,0.001851932],"category_scores_gemma":[0.002764281,0.0004155205,0.000844506,0.002136383,0.0004021872,0.0004668712,0.00034313,0.0003422272,0.0004527204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005939023,"about_ca_system_score_gemma":0.0006718436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0102207,"about_ca_topic_score_gemma":0.007514314,"domain_scores_codex":[0.998328,0.00024515,0.0003317275,0.0004493191,0.0004610005,0.0001847306],"domain_scores_gemma":[0.9965777,0.0006160178,0.001599573,0.0004620903,0.000455503,0.000289201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008766118,0.00001011399,0.9986564,0.00001055261,0.0000481979,0.0003091691,0.00004538781,0.00002734677,0.0001470818,0.00001057349,0.00006254284,0.0005850051],"study_design_scores_gemma":[0.000006472389,0.0001421279,0.9972071,0.000009762349,0.00006701427,0.001728207,0.0001308229,0.0001630643,0.0001096495,0.00001062867,0.0004187801,0.000006341749],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974171,0.0005761024,0.0002155452,0.00002917246,0.000005845262,0.00002404238,0.001026964,0.000006334585,0.0006988556],"genre_scores_gemma":[0.9989482,0.0001770976,0.00008278979,0.00003374481,0.000008989579,0.00001396446,0.0006190256,0.000004173441,0.0001122171],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0102207,"threshold_uncertainty_score":0.02032244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02002448497360877,"score_gpt":0.324140887230746,"score_spread":0.3041164022571373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}