{"id":"W2791395562","doi":"10.1177/2472555218763310","title":"ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter","year":2018,"lang":"en","type":"article","venue":"SLAS DISCOVERY","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Biomedical Imaging and Bioengineering; National Eye Institute; Canadian Institutes of Health Research; Canada Research Chairs; Cystic Fibrosis Canada; Cystic Fibrosis Foundation Therapeutics; National Institutes of Health; Cystic Fibrosis Foundation","keywords":"Domain (mathematical analysis); Nucleotide; Chemistry; Cell biology; Molecular biology; Biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005381336,0.0002313146,0.000447547,0.000184636,0.0001122073,0.0000478609,0.0001624531,0.00006875743,0.0003229848],"category_scores_gemma":[0.0005021395,0.0001903382,0.000179738,0.0004437701,0.0003103585,0.0002951934,0.00009354577,0.0002026395,0.0001134762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001250014,"about_ca_system_score_gemma":0.0002268577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001230318,"about_ca_topic_score_gemma":0.00001115224,"domain_scores_codex":[0.9975837,0.00008602472,0.0005079583,0.0004947039,0.000801311,0.0005263191],"domain_scores_gemma":[0.9985523,0.0002406505,0.0002740076,0.0006197031,0.0001250516,0.0001882994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001475191,0.0003642098,0.03390139,0.0002772126,0.00006977697,0.0001065004,0.0001460051,0.0006517466,0.9578349,0.00008220354,0.004800815,0.0002900838],"study_design_scores_gemma":[0.004903514,0.00480204,0.07428111,0.001493423,0.000135552,0.00002685992,0.0008050109,0.01514208,0.8909513,0.0005392581,0.006179048,0.000740738],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860656,0.0001193187,0.004278549,0.0002001196,0.0001937474,0.0004812557,0.00007525826,0.00005767799,0.008528475],"genre_scores_gemma":[0.9690346,0.000006753723,0.02885961,0.0001259071,0.0002479926,0.000007223238,0.00006210401,0.00005842719,0.001597402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06688351,"threshold_uncertainty_score":0.7761767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0115978658155371,"score_gpt":0.2801941698202321,"score_spread":0.268596304004695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}