{"id":"W2791409969","doi":"10.1136/bmj.k698","title":"Key design considerations for adaptive clinical trials: a primer for clinicians","year":2018,"lang":"en","type":"article","venue":"BMJ","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"Bill and Melinda Gates Foundation","keywords":"Clinical trial; Adaptive design; Computer science; Resource (disambiguation); Key (lock); Psychological intervention; Clinical study design; Research design; Risk analysis (engineering); Drug trial; Medical physics; Medicine; Management science; Intensive care medicine; Engineering; Psychiatry; Pathology; Computer security","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.08004504,0.0002329358,0.001677058,0.00005561908,0.0002476379,0.00005949972,0.0002038016,0.0004406294,0.0004242769],"category_scores_gemma":[0.8862401,0.0001859832,0.0007820483,0.00009719199,0.0005068943,0.00005620324,0.00005641663,0.0002283106,0.00009949572],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003057152,"about_ca_system_score_gemma":0.0004435697,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002557469,"about_ca_topic_score_gemma":0.00001559802,"domain_scores_codex":[0.9878659,0.00658071,0.004276298,0.000605088,0.0002504571,0.0004215148],"domain_scores_gemma":[0.2271218,0.7696115,0.001361148,0.0006980884,0.0009799917,0.0002274725],"domain_codex":null,"domain_gemma":"methods","domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.002217467,0.0003803088,0.00002059883,0.00003592868,0.0003783372,0.000001720828,0.0001486943,9.956279e-7,0.00003507764,0.4802012,0.494188,0.02239172],"study_design_scores_gemma":[0.00427155,0.002459488,0.00003525224,0.00006953437,0.000614351,0.000002973884,0.00007779279,0.004824508,0.0007724234,0.9715386,0.01508016,0.0002533866],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.00008287303,0.0000160358,0.9824475,0.004084447,0.002833297,0.008480642,0.0004648845,0.0001264803,0.001463861],"genre_scores_gemma":[0.002749128,0.000006734153,0.9857111,0.001900179,0.007224127,0.001678661,0.000002159702,0.00006744993,0.0006604855],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.8061951,"threshold_uncertainty_score":0.9472872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9552590505586375,"score_gpt":0.7305588347048191,"score_spread":0.2247002158538184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}