{"id":"W2791427360","doi":"10.1126/scitranslmed.aam6474","title":"Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability","year":2018,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Ardelyx; National Institute of Diabetes and Digestive and Kidney Diseases; Kidney Foundation of Canada","keywords":"Paracellular transport; Phosphate; Sodium; Chemistry; Permeability (electromagnetism); Gastrointestinal tract; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001193558,0.0003592099,0.0003293162,0.0001986611,0.0001158674,0.0002845578,0.0002789457,0.0002571996,0.001548602],"category_scores_gemma":[0.0001463653,0.0001510277,0.0003278727,0.0001176186,0.0002224842,0.0002410431,0.0001865263,0.0008307002,0.0001886436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001934462,"about_ca_system_score_gemma":0.0002441739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007417289,"about_ca_topic_score_gemma":0.001481389,"domain_scores_codex":[0.9999101,0.00001625713,0.00001050121,0.00001749232,0.00002390264,0.00002166726],"domain_scores_gemma":[0.9999156,0.0000158878,0.00002288116,0.0000072182,0.000009222195,0.00002927958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001119438,0.0001371843,0.0002473892,0.0001076551,0.00002041884,0.00005624106,0.00001521912,0.00005685644,0.9938208,0.00005548917,0.00007511087,0.004288183],"study_design_scores_gemma":[0.0002954018,0.004241273,0.01082313,0.00001858803,0.00008914226,0.0004718619,0.00006854252,0.001134702,0.9791942,0.0001283679,0.003523072,0.00001166266],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934199,0.002481877,0.001895614,0.0001912934,0.00004804377,0.00004524387,0.000271672,0.0001019754,0.001544263],"genre_scores_gemma":[0.9938595,0.001922772,0.001643116,0.0001385375,0.00001450116,0.00004865271,0.0004736147,0.00001841729,0.001881017],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001548602,"threshold_uncertainty_score":0.005180538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02870929708292402,"score_gpt":0.308096648846345,"score_spread":0.2793873517634209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}