{"id":"W2791428099","doi":"10.1016/j.stem.2018.02.002","title":"Vangl2/RhoA Signaling Pathway Regulates Stem Cell Self-Renewal Programs and Growth in Rhabdomyosarcoma","year":2018,"lang":"en","type":"article","venue":"Cell stem cell","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Center for Research Resources; National Cancer Institute; National Institutes of Health; Alex's Lemonade Stand Foundation for Childhood Cancer; Sick Kids Foundation; Dana-Farber/Harvard Cancer Center","keywords":"RHOA; Zebrafish; Biology; Wnt signaling pathway; Rhabdomyosarcoma; Cell biology; Progenitor cell; Cell growth; Cancer research; Stem cell; Gene knockdown; Signal transduction; Cell culture; Genetics; Sarcoma; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003854934,0.0003777799,0.0003025092,0.00008704558,0.0001513252,0.0000932045,0.0003431717,0.0003197006,0.00003543496],"category_scores_gemma":[0.000001482777,0.0003590542,0.0001002259,0.0002229017,0.0001424495,0.00001174013,0.0002262669,0.0001523096,0.00004318397],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004716129,"about_ca_system_score_gemma":0.000140202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003193731,"about_ca_topic_score_gemma":0.00002455448,"domain_scores_codex":[0.9978471,0.0001151138,0.0004407009,0.0007639019,0.0002298408,0.0006032733],"domain_scores_gemma":[0.9991302,0.00002657504,0.0001854455,0.0003313471,0.0001525719,0.0001738384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001175613,0.0002733248,0.02576457,0.0002665471,0.00003532756,0.00002297685,0.001081495,0.00001038278,0.9670032,0.00001487197,0.0007914986,0.004618264],"study_design_scores_gemma":[0.001209215,0.0004528988,0.0002204346,0.00005529923,0.00002691856,0.000006650487,0.0003858666,0.00005313671,0.9860724,0.00008025728,0.01092689,0.0005100237],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867544,0.003836066,0.0001201449,0.00002532548,0.0002957378,0.0004067931,0.000004789385,0.00006211527,0.008494587],"genre_scores_gemma":[0.9916579,0.000189841,0.001486634,0.00009518188,0.0003691811,0.0000586387,0.00006762317,0.00006729607,0.006007739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02554413,"threshold_uncertainty_score":0.9998862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008122581867462782,"score_gpt":0.192624854723352,"score_spread":0.1845022728558892,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}