{"id":"W2791444686","doi":"10.1084/jem.20172222","title":"Caspase-1 self-cleavage is an intrinsic mechanism to terminate inflammasome activity","year":2018,"lang":"en","type":"article","venue":"The Journal of Experimental Medicine","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":562,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Australian Research Council; University of Queensland; Australian Cancer Research Foundation; Fonds de Recherche du Québec - Santé; Kennedy Trust for Rheumatology Research","keywords":"Inflammasome; Tetramer; Caspase; Cell biology; Caspase 1; Caspase 3; Chemistry; AIM2; Caspase 8; Cleavage (geology); Apoptosis; Biophysics; Biology; Programmed cell death; Biochemistry; Enzyme; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006992012,0.0004634329,0.000664052,0.0002829538,0.0002632586,0.0008608207,0.0003755471,0.0005565992,0.001390637],"category_scores_gemma":[0.0008373381,0.0002124003,0.0005552761,0.0002261403,0.0004569904,0.001033251,0.0004141844,0.001400957,0.0007437989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006626229,"about_ca_system_score_gemma":0.0004366535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008678262,"about_ca_topic_score_gemma":0.00009510552,"domain_scores_codex":[0.9992449,0.0001351942,0.00009062255,0.0002223894,0.0001830689,0.0001237742],"domain_scores_gemma":[0.9993623,0.00009624988,0.0002435864,0.0001173677,0.0001172603,0.00006329824],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001329224,0.00003324744,0.0008568424,0.0001346556,0.00001824592,0.0001555091,0.00004630103,0.0001353257,0.9918588,0.001329579,0.00008979858,0.005208863],"study_design_scores_gemma":[0.00001638039,0.0002893333,0.004223297,0.00001782832,0.00001273629,0.001194023,0.00002847008,0.0005648923,0.9887143,0.0007509978,0.004177554,0.00001029552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.899914,0.01714709,0.07670613,0.000647371,0.0002566395,0.0001386761,0.000658569,0.0005806689,0.003950836],"genre_scores_gemma":[0.9841335,0.002293181,0.01126942,0.0001107056,0.00006477573,0.00004498443,0.0002946211,0.00003196256,0.001756919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001390637,"threshold_uncertainty_score":0.004807711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01200095223394119,"score_gpt":0.2882331801390687,"score_spread":0.2762322279051275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}