{"id":"W2791456541","doi":"10.1016/s0735-1097(18)32296-4","title":"PCSK9 INHIBITION: REAL WORLD APPLICATION AND CHALLENGES TO ACHIEVE UNMET CHOLESTEROL TARGETS IN CANADIAN ATHEROSCLEROTIC HEART DISEASE, THE PRACTICAL STUDY","year":2018,"lang":"en","type":"article","venue":"Journal of the American College of Cardiology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Cambridge Cardiac Care Centre","funders":"","keywords":"Medicine; PCSK9; Ldl cholesterol; Cholesterol; Atherosclerotic cardiovascular disease; Cardiology; Internal medicine; Reduction (mathematics); Cholesterol lowering; Disease; Heart disease; LDL receptor; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008231453,0.001290073,0.001214402,0.000404381,0.002531051,0.00304891,0.002058712,0.00144028,0.004818889],"category_scores_gemma":[0.01724905,0.0003113879,0.000958637,0.001804529,0.001682132,0.001056046,0.001307448,0.002448539,0.0005352232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02456425,"about_ca_system_score_gemma":0.05056734,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.8953835,"about_ca_topic_score_gemma":0.9416717,"domain_scores_codex":[0.9966407,0.001008981,0.0001415477,0.0003510778,0.001244341,0.0006135053],"domain_scores_gemma":[0.9939408,0.001729356,0.0004560108,0.0004445707,0.002419885,0.001009369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.02555828,0.004787269,0.2350415,0.002850085,0.001830677,0.001083827,0.002942619,0.01796356,0.004213933,0.01494381,0.2044158,0.4843687],"study_design_scores_gemma":[0.009059802,0.01194806,0.7160213,0.001641062,0.004293156,0.001021127,0.0107931,0.03334076,0.006157446,0.01280009,0.1921944,0.0007296962],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7890827,0.02749203,0.006661606,0.08940861,0.001298737,0.00125157,0.01762407,0.0005032959,0.06667735],"genre_scores_gemma":[0.9715527,0.00773642,0.007823159,0.004148609,0.0002346007,0.0002846994,0.003433098,0.00006394375,0.004722842],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1046165,"threshold_uncertainty_score":0.2104652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02559373766974597,"score_gpt":0.3063917488853402,"score_spread":0.2807980112155942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}