{"id":"W2791469985","doi":"10.1158/1078-0432.ccr-17-1715","title":"Administration of Hypoxia-Activated Prodrug Evofosfamide after Conventional Adjuvant Therapy Enhances Therapeutic Outcome and Targets Cancer-Initiating Cells in Preclinical Models of Colorectal Cancer","year":2018,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Work & Health; Structural Genomics Consortium; University of Toronto; Princess Margaret Cancer Centre; University Health Network","funders":"Institute of Cancer Research; Canadian Institutes of Health Research; Government of Canada","keywords":"Prodrug; Colorectal cancer; Hypoxia (environmental); Tumor hypoxia; Medicine; Cancer research; In vivo; Cancer cell; Cancer; Radiation therapy; Chemoradiotherapy; Combination therapy; Pharmacology; Oncology; Internal medicine; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001587334,0.0004419863,0.0004819062,0.0002424806,0.0001002939,0.0001903937,0.0002113466,0.0002953249,0.0009776303],"category_scores_gemma":[0.00009367226,0.0001165193,0.0001788115,0.0001509394,0.0001832767,0.0001968433,0.00009060356,0.0006960074,0.0001530033],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002960502,"about_ca_system_score_gemma":0.0002701923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007911635,"about_ca_topic_score_gemma":0.001521362,"domain_scores_codex":[0.9999067,0.00001555568,0.000006817882,0.00001916175,0.00002000499,0.00003175828],"domain_scores_gemma":[0.9998918,0.00001611816,0.00003418562,0.00001198274,0.000008249231,0.0000377473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002279544,0.001008669,0.000260557,0.00007167874,0.00001725878,0.00003773021,0.00002021874,0.0003311794,0.9901332,0.00006826815,0.0001391129,0.005632625],"study_design_scores_gemma":[0.0003411974,0.01985724,0.004834944,0.000008084495,0.00005473878,0.0001961825,0.00001783141,0.001734392,0.9715029,0.00002111374,0.00142524,0.00000600999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973689,0.0007964053,0.0007345091,0.00004935525,0.00003623056,0.00006706639,0.0001379532,0.00006766572,0.0007418434],"genre_scores_gemma":[0.9973199,0.0003999259,0.0009806837,0.00001997009,0.0000150324,0.00004899786,0.0002103431,0.000009203959,0.0009960659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009776303,"threshold_uncertainty_score":0.003270507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1699524730555657,"score_gpt":0.4820761485974125,"score_spread":0.3121236755418467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}