{"id":"W2791493808","doi":"10.1016/j.immuni.2018.03.006","title":"Cbl Ubiquitin Ligases Control B Cell Exit from the Germinal-Center Reaction","year":2018,"lang":"en","type":"article","venue":"Immunity","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":77,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"National Cancer Institute; Canadian Institutes of Health Research; Feinstein Institutes for Medical Research; National Institutes of Health","keywords":"Germinal center; Affinity maturation; Ubiquitin; Biology; Cell biology; Affinity chromatography; Molecular biology; CD40; B cell; Transcription factor; B-cell receptor; Immunoglobulin light chain; Antibody; Biochemistry; Genetics; In vitro; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.000345622,0.0002567196,0.0003175891,0.00008258081,0.0007734361,0.00003164845,0.0005908617,0.0003646494,0.002059381],"category_scores_gemma":[0.00009199357,0.0001818915,0.0001531202,0.0001620494,0.000871537,0.0001234668,0.000186227,0.00076437,0.006278614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003593677,"about_ca_system_score_gemma":0.00004825488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003643033,"about_ca_topic_score_gemma":0.0003367218,"domain_scores_codex":[0.9980255,0.0007773177,0.0003566358,0.0003004068,0.00004082732,0.0004992923],"domain_scores_gemma":[0.9981666,0.0006045224,0.0002078708,0.0008579513,0.0001408871,0.00002217195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004129377,0.0003939535,0.001874255,0.000003483591,0.0001419742,0.00000486044,0.0005808818,6.595025e-8,0.9740066,0.00004315389,0.01914982,0.003387989],"study_design_scores_gemma":[0.002420934,0.0003255914,0.008362264,0.00002400857,0.00008164275,0.00005807342,0.0006060856,0.000001438363,0.6533463,0.0002512919,0.3343261,0.0001962238],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849038,0.003140002,0.00009935947,0.0007927908,0.002101429,0.0002613746,0.0001346574,0.0001414087,0.008425242],"genre_scores_gemma":[0.9932597,0.0002536331,0.00002192875,0.00125797,0.0002577776,0.00002797741,0.0002398565,0.00002399308,0.004657112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3206603,"threshold_uncertainty_score":0.9988528,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01485036647798452,"score_gpt":0.2339951859435635,"score_spread":0.219144819465579,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}