{"id":"W2791495656","doi":"10.1093/hmg/ddy039","title":"Human cis-acting elements regulating escape from X-chromosome inactivation function in mouse","year":2018,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"National Human Genome Research Institute; National Institute on Drug Abuse; National Institute of Neurological Disorders and Stroke; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Cancer Institute; National Institutes of Health","keywords":"Biology; Gene; Genetics; X-inactivation; X chromosome; Regulation of gene expression; DNA methylation; Chromosome; TBX1; Gene expression; Promoter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001927651,0.0001984514,0.0001796335,0.0005731548,0.0001320854,0.0002591928,0.0002077727,0.000277886,0.002130738],"category_scores_gemma":[0.0001116752,0.0002493789,0.0003375714,0.0002288317,0.0002096671,0.0001284131,0.0002622713,0.0003290162,0.0009091474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002098823,"about_ca_system_score_gemma":0.0001586296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005794432,"about_ca_topic_score_gemma":0.0009417811,"domain_scores_codex":[0.999843,0.00002048821,0.00001570622,0.00004251492,0.00004748082,0.00003074566],"domain_scores_gemma":[0.9998999,0.00002481656,0.00002968273,0.00001845858,0.000007681327,0.00001958522],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000620188,0.00001126359,0.000244231,0.00001906854,0.000003560807,0.00004270656,0.00001964589,0.00005574641,0.9981272,0.0002063754,0.00002303159,0.001185285],"study_design_scores_gemma":[0.00003384623,0.0002676744,0.01685786,0.00002688975,0.00003321844,0.000730667,0.00006443089,0.0007526846,0.9711821,0.0002597189,0.00978082,0.00001000721],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981204,0.003779888,0.009312169,0.0001096792,0.00003871419,0.00006573959,0.001410424,0.0002944787,0.003784866],"genre_scores_gemma":[0.9845936,0.001609526,0.00527308,0.00007695184,0.000004681137,0.00005801843,0.002213986,0.00007465965,0.006095462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002130738,"threshold_uncertainty_score":0.00712806,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0199352390698431,"score_gpt":0.2860517102726614,"score_spread":0.2661164712028182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}